| 尿样中苯骈二氮杂Zhu类药物筛选分析研究 |
| |
| 引用本文： | Shen BH,Shen M,Zhuo XY. 尿样中苯骈二氮杂Zhu类药物筛选分析研究[J]. 法医学杂志, 2002, 18(1): 22-25 |
| |
| 作者姓名： | Shen BH Shen M Zhuo XY |
| |
| 作者单位： | 1. 司法部司法鉴定科学技术研究所上海,200063
2. 复旦大学基础医学院法医教研室,上海,200032 |
| |
| 基金项目： | 上海市科委资助项目,002512079, |
| |
| 摘 要： | 目的建立尿样中苯骈二氮杂类药物两种筛选分析方法.方法用GC/ECD、GC/MS直接测定苯骈二氮杂类药物原体和GC/ECD、GC/MS测定1,4-苯骈二氮杂类药物的酸水解产物苯甲酮同系物.结果GC/ECD直接测定苯骈二氮杂类药物方法,大部分药物的回收率为60%～90%,线性范围为20～200ng/ml尿,线性相关系数大于0.99,最低检出限达0.5ng/ml～10ng/ml.结论所建两种方法各有其特点又可相互补充,已成功地应用于司法鉴定实践.
|
| 关 键 词： | 苯骈二氮杂类药物 苯甲酮类同系物 |
| 文章编号： | 1004-5619(2002)01-0022-04 |
| 修稿时间： | 2001-11-02 |
Screening of benzodizepines and their metabolites in urine |
| |
| Shen Bao-hua,Shen Min,Zhuo Xian-yi. Screening of benzodizepines and their metabolites in urine[J]. Journal of Forensic Medicine, 2002, 18(1): 22-25 |
| |
| Authors: | Shen Bao-hua Shen Min Zhuo Xian-yi |
| |
| Affiliation: | Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063. |
| |
| Abstract: | Objective Screen seventeen benzodizepines and their metabolitesin urine by GC/ECDand GC/MS . Methods They were GC (GC/ECD, GC/MS) assay of benzodizepines and GC (GC/ECD, GC/MS) assay of benzophenones of acid-hydrolytic products of 1,4-benzodizepines. Results The methods were simple and sensitive. The recoverys were 60%to 90%of most benzodizepines, linear calibration curves were 20ng/ml-200ng/ml(r >0.99), and detection limits were 0.5ng/ml-10ng/ml. Conclusion They methods were evaluated with human urine samples. |
| |
| Keywords: | GC/ECD GC/MS |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
|
