One-step liquid-liquid extraction of cocaine from urine samples for gas chromatographic analysis |
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Authors: | Farina Marcelo Yonamine Maurício Silva Ovandir A |
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Affiliation: | College of Pharmacy, Universidade Regional Integrada do Alto Uruguai e Miss?es, URI Av. Sete de Setembro, 1621 CEP 99700-000 Erechim, RS, Brazil. |
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Abstract: | An improved technique for cocaine extraction from urine samples for gas chromatographic (GC) analysis is described. Employing a simple liquid-liquid extraction (LLE) of cocaine with a mixture of ethyl ether:isopropanol (9:1) the method presents a mean recovery of 74.49%. Limit of detection (LOD) and limit of quantification (LOQ) were 5 and 20 ng/ml, respectively. The method is highly precise (coefficient of variation (CV) <8%) and linear from 20 to 2000 ng/ml. It can he applied to detect the presence of cocaine in urine as a marker of its recent use in drug abuse treatment protocols. |
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