川芎嗪和血塞通对糖尿病肾病患者尿微量白蛋白的作用

目的:观察川芎嗪和三七总皂苷对2型糖尿病肾病患者尿微量白蛋白的影响。方法:44例患者随机分为3组,即川芎嗪组(给予川芎嗪注射液)、三七总皂苷组(给予血塞通注射液,主要成分为三七总皂苷)和对照组(不用川芎嗪、血塞通)。疗程均为2周,3组基础治疗措施相同。治疗前后分别测定24 h尿微量白蛋白排泄率。结果:川芎嗪组和三七总皂苷组,治疗后24 h尿微量白蛋白排泄率明显下降,差异有显著性(P<0.01);对照组治疗前后24 h尿微量白蛋白排泄率比较,差异无显著性。结论:川芎嗪和三七总皂苷能够降低2型糖尿病肾病患者尿微量白蛋白排泄率,延缓糖尿病肾病的发展。

The Effect of Ligustrazine and Xuesaitong on Microalbuminuria in Patients with Diabetic Nephropathy

Objective: To observe the effects of Ligustrazine and Panax Notoginseng saponins(PNS) on the urinary microalbumin in patients with type-2 diabetes.Methods: Forty-four patients with type-2 diabetes were randomly divided into three groups,namely,Ligustrazine group treated with Ligustrazine Injection,PNS group treated with Xuesaitong Injection(an injection mainly composed of PNS) and control group untreated with Ligustrazine and PNS.The treatment courses of three groups were 2 weeks.The same therapeutic measures were given to three groups.The excretion rate of urinary microalbumin during 24 hours was determined before and after treatment.Results: After treatment,the excretion rate of urinary microalbumin during 24 hours of Ligustrazine group and PNS group decreased significantly(P<0.01), while there was no significant difference in above-mentioned index of control group before and after treatment.Conclusion: Ligustrazine and PNS could decrease the excretion rate of microalbumin during 24 hours in patients with diabetic nephropathy,and delay the development of diabetic nephropathy.