| 活血舒心合剂对心肌缺血再灌注大鼠Fas蛋白表达的影响 |
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| 作者姓名： | 陈慧 杨玉兴 |
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| 作者单位： | 中国人民解放军兰州军区第二门诊部,中国人民解放军兰州军区总医院干二科 甘肃兰州730000 |
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| 摘 要： | 目的:探讨中药自拟方"活血舒心合剂"对大鼠缺血再灌注模型心肌细胞中Fas蛋白表达的影响.方法:采用冠状动脉结扎-松结法复制大鼠心肌缺血再灌注损伤模型,以SABC免疫组化法检测心肌细胞中Fas蛋白表达的变化.结果:与假手术组比较,缺血再灌注组心肌细胞Fas蛋白阳性表达明显增加(P<0.01),经活血舒心合剂干预后,Fas蛋白阳性表达下降(P<0.05).结论:活血舒心合剂可通过下调凋亡相关基因Fas蛋白的表达来保护缺血再灌注损伤心肌.
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| 关 键 词： | 活血舒心合剂 细胞凋亡 Fas蛋白 心肌缺血再灌注损伤 |
| 修稿时间： | 2004/4/19 0:00:00 |
Influence of Huoxue Shuxin Mixture on Expression of Fas Protein in Rat Hearts with Myocardial Ischemia Reperfusion Injury |
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| Authors: | CHEN Hui YANG Yu-xing |
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| Abstract: | Objective:To study the influence of Huoxue Shuxin mixture on the expression of Fas protein in rat hearts with myocardial ischemia-reperfusion injury(MI-RI).Method:MI-RI models were performed by a ligation and release of coronary artery in rats.The changes of Fas protein expression were determined by SABC immunohistochemistry.Result:Compared with shamoperation group,the expression of Fas protein in myocytes increased significantly in MI-RI group;Compared with MI-RI group,the expression of Fas protein decreased gradually in Huoxue Shuxin mixture treated group(P<0.05).Conclusion:Huoxue Shuxin mixture can protect myocardial cell with MI-RI by adjusting the expression of Fas protein. |
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| Keywords: | Huoxue Shuxin mixture Apoptosis Fas protein Myocardial ischemia-reperfusion injury |
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