冠心康对兔血浆高同型半胱氨酸含量的影响

目的:探讨中药验方冠心康抗动脉粥样硬化的机制。方法:将30只兔随机分为对照组、模型组、干预组,喂食高蛋氨酸饲料,复制兔高同型半胱氨酸(Hcy)血症模型,0,4,8周末用循环酶法检测血浆Hcy水平。结果:第4周末和第8周末,模型组Hcy均显著升高,与正常对照组比较,差异有统计学意义;干预组第4周末和第8周末Hcy含量显著降低,与模型组比较,差异均有统计学意义(P<0.05)。结论:冠心康可促进Hcy的代谢,有效防治高Hcy血症,延缓或阻止动脉粥样硬化的形成。

Effect of Guan Xin Kang on the Levels of Homocysteine in Rabbits with Hyperhomocysteinemia

Objective: To explore the antiatherogenic mechanism of Guan Xin Kang(a proved recipe in traditional Chinese medicine).Method:Thirty rabbits were randomly divided into control group,model group and intervention group.The rabbit model with hyperhomocysteinemia was constructed by feeding homomethionin diets.The levels of plasma homocysteine were assayed using cyclophorase method at the 0,4th,8th week,respectively.Result:The plasma levels of homocysteine(Hcy) in model group increased significantly as compared with those of control group at the 4th,8th week.The plasma levels of Hcy in intervention group significantly decreased as compared with those of model group at the 4th,8th week.Conclusion: Guan Xin Kang could improve the metabolism of Hcy,prevent and cure hyperhomocysteinemia efficiently,delay or prevent the formation of atherosclerosis.