肺气虚证大鼠血液流变性指标与内皮素、血栓素水平的相关性研究

目的 :探讨肺气虚证大鼠的血液流变性变化与内皮素 (ET)、血栓素 (TXB2 )变化的相关性。方法 :将 6 0只大鼠随机分为模型组与对照组 ,复制肺气虚证模型 ,分别检测血液流变性指标和ET、TXB2 水平。结果 :模型组与对照组比较 ,全血黏度 (高切、低切 )、血浆黏度、红细胞比容、红细胞聚集指数及纤维蛋白原均升高 ,差异有显著性 (P <0 .0 1或P <0 .0 5 ) ;模型组ET和TXB2 明显升高 ,与对照组相比 ,差异有显著性 (P <0 .0 1)。模型组全血黏度与ET、TXB2 呈正相关 (r =0 .95 7,P <0 .0 5 ;r =0 .992 ,P <0 .0 1)。结论 :肺气虚大鼠存在“血瘀”现象 ,且血浆中的ET、TXB2 含量随肺气虚证逐渐加重而呈上升趋势。

Research on Relativity between Hemorrheology Indexes and the Levels of Endothelin and Thromboxane B2 in Rats with Lung Qi Deficiency Syndrome

Objective:To study the relativity between hemorrheology indexes and the levels of thromboxane B 2(TXB 2) and endothelin(ET) in rats with lung Qi deficiency syndrome.Method:Sixty rats were randomly divided into model group and control group.Hemorrheology indexes and the levels of TXB 2 and ET were determined.Result: In model group, the whole blood viscidity ,plasma viscidity, hematocrit, erythrocyte aggregation index and fibrinogen all increased in comparison with those of control group (P<0.01 or P<0.05),while the levels of ET and TXB 2 increased significantly (P<0.01 ).The whole blood viscidity was positively related to ET and TXB 2 separately(r=0.957,P<0.05;r=0.992,P<0.01 ).Conclusion: Lung Qi deficiency syndrome has the phenomena of blood stasis,and the levels of ET and TXB 2 in plasma tends to increase with lung Qi deficiency syndrome aggravating gradually.