首页 | 本学科首页   官方微博 | 高级检索  
     检索      

二丙酰基莲心碱对猪冠状动脉条的影响
作者姓名:罗云  李荣凌  杨健
作者单位:武汉大学人民医院药学部,湖北武汉430060
摘    要:目的:观察二丙酰基莲心碱拮抗KCl、乙酰胆碱和组胺所致猪冠状动脉条收缩的作用.方法:体外平滑肌实验方法,观察二丙酰基莲心碱对KCl、乙酰胆碱和组胺所致猪冠状动脉条收缩曲线的影响以及在无Ca2+克氏液中,对组胺引起猪冠状动脉条第一相收缩和Ca2+引起第二相收缩的影响.结果:不同剂量二丙酰基莲心碱均可使KCl、乙酰胆碱和组胺所致冠脉条收缩量效曲线呈非竞争性拮抗作用,对冠脉条第一相和第二相收缩都有明显的抑制作用.结论:二丙酰基莲心碱具有扩张冠脉的作用,此作用与拮抗细胞内钙的释放和抑制外钙内流有关.

关 键 词:二丙酰基莲心碱  冠状动脉  氯化钾  乙酰胆碱  组胺
收稿时间:2005/6/4 0:00:00

Effect of O, O-Dipropionyl-liensinine on the Strips of Porcine Coronary Artery
Authors:LUO Yun  LI Rong-ling  YANG Jian
Abstract:Objective: To observe the antagonism of on contraction of porcine artery strips induced by KCl,acetyl choline and Histamine respectively.Method: Using experimental method of porcine coronary arterial smooth muscle in vitro,the effect of O,O-Di propionyl-liensinine on pig arteria coronary contraction induced by KCl,acetyl choline and histamine,and the effect on the intracellular Ca~(2+)-dependent contraction induced by histamine and the extracellular Ca~(2+)-dependent contraction induced by CaCl_2 in Krebs solution are observed.Result: Different dosage of O,O-Dipropionyl-liensinine had noncompetitively antagonizing effect on KCl,acetylcholine and Histamine cumulative dose-response curves.O,O-Di propionyl-liensinine and ver oinhibited intracellular Ca~(2+)-dependent contraction induced by Histamine,and show relatively small effect on the extracellular Ca~(2+)-dependent contraction induced by CaCl_2.Conclusion: O,O-Dipropionyl-Liensinine has a significant relaxing effect on contraction of coronary artery,and has an antagonistic effect on the two kinds of contractions.
Keywords:O  O-Dipropionyl-liensinine  Coronary artery  KCl  Acetylcholine  Histamine
点击此处可从《》浏览原始摘要信息
点击此处可从《》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号