| 朊毒体蛋白的构象及其特性的研究进展 |
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| 引用本文： | 陈豪泰,刘永生,张杰,吴润,刘湘涛. 朊毒体蛋白的构象及其特性的研究进展[J]. 中国兽医科学, 2007, 37(12): 1094-1098 |
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| 作者姓名： | 陈豪泰 刘永生 张杰 吴润 刘湘涛 |
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| 作者单位： | 1. 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部畜禽病毒学重点,实验室,甘肃兰州,730046
2. 甘肃农业大学动物医学院,甘肃,兰州,730070 |
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| 基金项目： | 国家自然科学基金;甘肃省自然科学基金;国家博士后科学基金;甘肃省科技攻关重点项目 |
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| 摘 要： | 概述了朊毒体(包括构象不同的细胞型朊毒体和痒病型朊毒体)蛋白的构象特征、朊毒体及其突变体的特性,阐明了PrPsc是由PrPc通过构象转变而成的,不同物种PrP的三维结构有相似的球形结构域(125~228位)和N-末端无规卷曲尾,其球形结构域均由3个螺旋(144~154、173~194和200~228位)以及1对反平行的β-折叠(128~131和161~164)组成,但其结构和表面电荷分布存在一些区别。
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| 关 键 词： | 朊毒体蛋白 构象 特性 |
| 文章编号： | 1673-4696(2007)12-1094-05 |
| 修稿时间： | 2007-06-23 |
Progress in conformation and property of prion proteins |
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| CHEN Hao-tai,LIU Yong-sheng,ZHANG Jie,WU Run,LIU Xiang-tao. Progress in conformation and property of prion proteins[J]. Chinese Veterinary Science, 2007, 37(12): 1094-1098 |
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| Authors: | CHEN Hao-tai LIU Yong-sheng ZHANG Jie WU Run LIU Xiang-tao |
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| Abstract: | Prion proteins including the cellular isoform of prion protein(PrPc) and the scrapie isoform of prion protein(PrPsc) were reviewed in the aspects of conformational characteristics,and properties of prion and its mutants.PrPsc was changed to PrPc through conformational change.PrP three-dimensional structures from different species have a similar globular domain from the 125 to 228 residues and a N-terminal flexibly disordered "tail".The globular domain contains three alpha-helices comprising the residues 144-154,173-194,200-228 and a short anti-parallel beta-sheet comprising the residues 128-131 and 161-164,but they were different in the structure and surface charge distribution. |
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| Keywords: | prion protein conformation property |
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