Myocardial sarcoidosis as a rare cause of sudden cardiac death |
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| Institution: | 1. Institute of Pathology, Municipal Hospital, Hanau, Germany;2. Senckenberg Centre of Pathology, University of Frankfurt/Main, Germany;3. Department of Cardiology, Bethanien Hospital, Frankfurt/Main, Germany;4. Centre of Forensic Medicine, University of Frankfurt/Main, Germany;1. Alzahra Cardiovascular Charitable Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;2. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran;1. Department of Myocardium, Pericardium and Aorta Diseases, Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil;2. Department of Infection Control, Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil;3. Department of Microbiology, Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil;4. Senior Lecturer, Unigranrio, Rio de Janeiro, Brazil;5. Infectious Diseases Inpatient Unit, Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil;1. Department of Internal Medicine, OhioHealth Doctors Hospital, Columbus, Ohio;2. Department of Cardiology, OhioHealth Doctors Hospital, Columbus, Ohio;3. OhioHealth Heart & Vascular Physicians, Section of Cardiac Electrophysiology, Department of Cardiology, Riverside Methodist Hospital, Columbus, Ohio |
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| Abstract: | Two relatively young women died suddenly due to myocardial sarcoidosis. Necropsy in both cases revealed compact infiltration of the ventricular septum by fibrous tissue. Histologic sections elucidated extensive granulomatous degeneration and giant cells of the Langhans' and foreign body type without central necrosis of the granulomas. Both women had been entirely free of symptoms, but in the second case of a 35-year-old, who had been 6 months pregnant, an ultrasound sonography of the heart had documented a suspicious area in the ventricular septum interpreted as a scar. Further investigations had been postponed until delivery. Isolated myocardial sarcoidosis should be taken into account as one possible cause of sudden death, especially in young people. |
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