| 氟苯尼考琥珀酸钠的制备及其在家兔体内的药代动力学特征 |
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| 引用本文： | 符华林,张伟,陈静,唐文,周凤,付强,邓凤英,胡俊. 氟苯尼考琥珀酸钠的制备及其在家兔体内的药代动力学特征[J]. 中国兽医科学, 2011, 0(6) |
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| 作者姓名： | 符华林 张伟 陈静 唐文 周凤 付强 邓凤英 胡俊 |
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| 作者单位： | 四川农业大学动物医学院动物疫病与人类健康四川省重点实验室; |
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| 基金项目： | 教育部“长江学者和创新团队发展计划”创新团队项目(IRT0848) |
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| 摘 要： | 用DMAP法制备氟苯尼考琥珀酸钠(Fl-SNa)。将6只家兔分别单剂量肌肉注射氟苯尼考和Fl-SNa,然后采用高效液相色谱(HPLC)法检测血药浓度;用DAS2.0药代动力学程序计算药代动力学参数。结果显示,成功制得Fl-SNa;给家兔单剂量注射氟苯尼考和Fl-SNa后,主要的药代动力学参数Cmax分别为8.863mg/L±0.254mg/L和7.363mg/L±0.085mg/L,tmax分别为1.0h和2.0h,AUC0-∞分别为28.851mg/L.h±0.494mg/L.h和39.187mg/L.h±0.413mg/L.h。结果表明,Fl-SNa达峰时间延长,峰浓度降低,生物利用度大大提高。证明高效液相色谱法准确、灵敏,适用于氟苯尼考血浆浓度的测定;制备的Fl-SNa与氟苯尼考相比生物利用度显著提高。
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| 关 键 词： | 氟苯尼考 氟苯尼考琥珀酸钠 家兔 药代动力学 高效液相色谱法 |
Preparation of florfenicol sodium succinate and its pharmacokinetics characteristics in rabbits |
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| FU Hua-lin,ZHANG Wei,CHEN Jing,TANG Wen,ZHOU Feng,FU Qiang,DENG Feng-ying,HU Jun. Preparation of florfenicol sodium succinate and its pharmacokinetics characteristics in rabbits[J]. Chinese Veterinary Science, 2011, 0(6) |
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| Authors: | FU Hua-lin ZHANG Wei CHEN Jing TANG Wen ZHOU Feng FU Qiang DENG Feng-ying HU Jun |
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| Affiliation: | FU Hua-lin,ZHANG Wei,CHEN Jing,TANG Wen,ZHOU Feng,FU Qiang,DENG Feng-ying,HU Jun(Key Laboratory of Animal Diseases and Human Health of Sichuan Province/College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China) |
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| Abstract: | Florfenicol sodium succinate(Fl-SNa) was prepared using 4-dimethylaminopyridine(DMAP) as catalyst.The blood samples from the rabbits intramuscularly-injected with a single dose of either florfenicol solution or Fl-SNa solution were collected to measure florfenicol concentrations in plasma by high performance liquid chromatography(HPLC).The pharmacokinetic parameters were analyzed with DAS2.0 software.In results,Fl-SNa was successfully prepared.The major pharmacokinetic parameters of florfenicol and Fl-SNa w... |
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| Keywords: | florfenicol Fl-SNa rabbit pharmacokinetics HPLC |
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