大鼠颅骨材料力学和骨质参数的增龄性变化

目的 通过检测大鼠颅骨材料力学和骨质参数,探讨二者关系及其与年龄的相关性.方法 48只健康雄性SD大鼠按年龄分为2、4、6、8、17、26、52和104周龄组,每组6只.利用KDⅡ-0.2型微机控制电子万能试验机压缩右侧颅盖骨检测其材料力学参数(极限载荷、压缩强度、压缩模量),之后分离颅骨骨片进行Micro-CT系统扫...

Age-Related Changes of Material Mechanics and Bone Material Parameters of Rat Skulls

Objective To study the relationship between material mechanics and bone material parameters of rat skulls and their correlation with age by examination of the parameters.Methods Forty-eight healthy male SD rats were divided into 2,4,6,8,17,26,52 and 104 week groups according to their age.Each group had six rats.The right cranium was compressed by KD Ⅱ-0.2 microcomputer controlled electronic universal testing machine,and material mechanics parameters(ultimate load,compression strength and compression modulus)were measured,then the skull slices were cut off and scanned by Micro-CT system to detect bone material parameters(skull thickness,bone mineral density,bone volume,and trabecular thickness).Results The differences in ultimate load,compression strength and compression modulus among all groups had statistical significance(P<0.05),and were positively correlated with age within 26 weeks(P<0.05).The differences in skull thickness,bone mineral density,bone volume and trabecular thickness among all groups had statistical significance(P<0.05),and were positively correlated with age within 52 weeks(P<0.05).All material mechanics parameters were positively correlated with bone material parameters(P<0.05).Conclusion There is a positive correlation between bone material parameters(skull thickness,bone mineral density,bone volume,trabecular thickness),material mechanics parameter(skull ultimate load,compression strength,compression modulus)and age in a certain range,which can be used to infer age.