| 中国成都地区汉族群体5个STR基因座的遗传多态性 |
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| 引用本文： | 陈国弟,辛军平,张林. 中国成都地区汉族群体5个STR基因座的遗传多态性[J]. 中国法医学杂志, 1999, 0(4) |
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| 作者姓名： | 陈国弟 辛军平 张林 |
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| 作者单位： | 华西医科大学法医物证教研室!成都，610041，华西医科大学法医物证教研室!成都，610041，华西医科大学法医物证教研室!成都，610041 |
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| 摘 要： | 采用PCR扩增，聚丙烯酰胺凝胶电泳分析技术，调查中国成都汉族群体DIS1656、D851179、D9S302、D185535及D195253等5个STR基因座的等位基因频率分布。D1S1656检出11个等位基因，35种基因型；DSS1179检出9个等位基因，32种基因型；D95302检出12个等位基因，50种基因型；D185535检出7个等位基因，20种基因型；D195253检出8个等位基因，28种基因型。5个STR基因座基因型频率分布符合Hardy-weinberg平衡（P＞0．05）。个人识别机率（DP）为0．92～0．98。分析了二代3口之家的遗传模式，证明5个STR基因座均符合孟德尔遗传规律。5个STR基因座PCR扩增采用同一条件，方法简单、快速、灵敏、重复性好，可用于法科学亲子鉴定和个人识别。
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| 关 键 词： | 法科学 短串联重复序列多态性 等位基因频率分布 |
Study of polymorphisms of five short tandem repeat systems in Chinese Han population in Chengdu |
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| Chen Guodi, Xin Junping, Zhang Lin,et al.. Study of polymorphisms of five short tandem repeat systems in Chinese Han population in Chengdu[J]. Chinese Journal of Forensic Medicine, 1999, 0(4) |
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| Authors: | Chen Guodi Xin Junping Zhang Lin et al. |
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| Affiliation: | Chen Guodi, Xin Junping, Zhang Lin,et al. / |
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| Abstract: | A population genetic study of five STR systems (D1S1656, D8S1179,D9S302, D18S535, D19S253) was carried out on Han population from Chengdu area byusing PCR method, and the allele distributions has been investigated. 11 alleles and 35genotypes could be identified for D1S1656 locus, 9 alleles and 32 genotypes for D8S1179 locus, 12 alleles and 50 genotypes for D9S302 locus, 7 alleles and 20 gentoypes for D18S535lcous, 8 alleles and 28 genotypes for D19S253 locus. No deviations from Hardy-Weinberg equilibrium were observed. The chance of exclusion were 0. 5776 ~ 0. 7984, and the discriminationg power 0. 92 ~ 0. 98. According to the results obtained in this study, it is suggestedthat all five loci are useful genetic markers for individual identification and paternity testingin forensic science practice as well for genetic study. |
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| Keywords: | Forensic science Polymorphism of short tandem repeat Distributions of alleles |
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