| 大鼠脑挫伤后FN表达与损伤时程关系的研究 |
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| 作者姓名： | Chen L Chen YJ Liu NG Li Z Zhao ZQ Gu YJ |
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| 作者单位： | 1. 复旦大学基础医学院法医学教研室,
2. 司法部司法鉴定科学技术研究所, |
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| 摘 要： | 为寻找推断脑损伤经历时间的可靠指标,采用自制自由落体撞击法致大鼠右顶叶局灶性脑挫伤模型,于不同时间段处死大鼠后,进行纤维连接蛋白的免疫组织化学及原位杂交法研究,结果发现纤维连接蛋白及其 mRNA表达水平与伤后经历时间有一定相关性,并能较好地鉴别死前脑挫伤和死后脑挫伤,可作为推断脑挫伤经历时间的参考指标之一。
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| 关 键 词： | 脑挫伤 损伤时间 纤维连接蛋白 免疫组织化学 原位杂交 |
| 文章编号： | 1004-5619（2001）01-0001-03 |
| 修稿时间： | 2000年5月9日 |
Study on the expression of fibronectin after cerebral contusion in rats for timing of injuries |
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| Chen L,Chen YJ,Liu NG,Li Z,Zhao ZQ,Gu YJ.Study on the expression of fibronectin after cerebral contusion in rats for timing of injuries[J].Journal of Forensic Medicine,2001,17(1):1-3. |
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| Authors: | Chen L Chen Y J Liu N G Li Z Zhao Z Q Gu Y J |
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| Institution: | Department of Forensic Medicine, Medical Center of Fudan University, Shanghai 200032. |
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| Abstract: | An experimental model of reproducible focal cerebral contusions in rats was made by a free-drop impacting right hemisphere. The expression of fibronectin and its mRNA after cerebral contusion were detected respectively by immunohistochemical staining and in situ hybridization. Results indicated that the expression of fibronectin and its mRNA increased after injury, and there existed a relationship between increased fibronectin and its mRNA and different intervals after brain injury. It is inferred that the expression of fibronectin and its mRNA can be used for timing of brain injuries and distinguishing antemortem and postmortem brain contusions. |
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| Keywords: | cerebral contusion timing of injury fibronectin immunohistochemistry in situ hybridization |
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