| 尿中氯胺酮及其代谢物检测的研究 |
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| 引用本文： | 卓先义,沈保华,马栋,向平,卜俊,刘伟. 尿中氯胺酮及其代谢物检测的研究[J]. 中国司法鉴定, 2005, 0(5): 18-19,33 |
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| 作者姓名： | 卓先义 沈保华 马栋 向平 卜俊 刘伟 |
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| 作者单位： | 司法部司法鉴定科学技术研究所 上海200063(卓先义，沈保华，马栋，向平，卜俊)，司法部司法鉴定科学技术研究所 上海200063(刘伟) |
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| 摘 要： | 目的建立氯胺酮滥用者尿中氯胺酮及其代谢物检测方法。方法尿液用有机溶剂液-液萃取,气相色谱/氮磷检测器、电子捕获检测器、氢火焰检测器和气-质联用仪测定。结果确认了尿液中氯胺酮的主要代谢物,尿液中氯胺酮及去甲氯胺酮的最小检测限均为2ng/mL,脱氢去甲氯胺酮的最小检测限为5ng/mL。结论所建方法快速、灵敏、准确,能够满足氯胺酮滥用者尿液检测的需要。
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| 关 键 词： | 尿液 氯胺酮 代谢物 气-质联用 气相色谱 |
| 文章编号： | 1671-2072-(2005)05-0018-02 |
| 修稿时间： | 2005-06-20 |
Determination of Ketamine and Its Major Metabolites in Urine by GC and GC/MS |
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| ZHUO Xian-yi,SHEN Bao-hua,MA Dong,XIANG Ping,BU Jun,LIU Wei. Determination of Ketamine and Its Major Metabolites in Urine by GC and GC/MS[J]. Chinese Journal of Forensic Sciences, 2005, 0(5): 18-19,33 |
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| Authors: | ZHUO Xian-yi SHEN Bao-hua MA Dong XIANG Ping BU Jun LIU Wei |
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| Abstract: | Objective To establish a method for determining ketamine and its major metabolites in urine. Methods The ketamine and its major metabolites in urine was extracted with organic solvent and detected by GC/NPD, GC/ECD, GC/FID and GC/MS. Results The major metabolites of ketamine in urine were identified. The limit of detection was 2ng/mL for ketamine and 5ng/mL for norketamine, the limit of quantitation of ketamine and norketamine was 10ng/mL. Conclusion The method is shown to be applicable to detecting ketamine and its major metabolites in urine. |
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| Keywords: | ketamine metabolites urine gas chromatography GC/MS |
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