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Population genetics of 30 insertion-deletion polymorphism in polish Populations |
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| Affiliation: | 1. Department of Forensic Medicine, Poznan University of Medical Sciences, Poznan, Poland;2. Department of Medical Genetics, Warsaw Medical University, Warsaw, Poland;3. Department of Forensic Medicine, Medical University of Bialystok, Bialystok, Poland;4. Department of Criminalistics and Forensic Medicine, University of Warmia and Mazury in Olsztyn, Poland |
| Abstract: | The Investigator DIPplex® kit (Qiagen) contains components for the simultaneous amplification and analysis of 30 biallelic autosomal InDels and amelogenin. The objective of this study was to estimate the diversity of the 30 markers in a Polish population sample (N = 389) and to evaluate their usefulness in forensic genetics. The DIPplex genotype distributions showed no significant deviation from Hardy-Weinberg rule expectations (Bonferroni corrected). The mean observed heterozygosity value is 0.4611, and the combined Matching Probability value is 1.08x10−13. The investigated marker set has been confirmed as a potential extension to standard STR - based kits or a separate informative system for individual identification and kinship analysis. |
| Keywords: | InDel polymorphism Investigator DIPplex Poland Population genetics Forensic efficiency |
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