重型颅脑损伤患者P300与智商的相关性

目的研究重型颅脑损伤患者认知功能的改变以及事件相关电位(event-related potential,ERP)中的P300成分与智商的关系。方法对40例重型颅脑损伤患者进行听觉P300检查并用中国修订韦氏成人智力全量表测定智商,另外用40例正常成年人作为对照组也进行P300的检查。结果病例组P300潜伏期较正常组明显延长(P<0.01),病例组P300的潜伏期与操作智商和总智商之间呈显著负相关(r=-0.335、-0.344,均P<0.05)。结论ERP是测定重型颅脑损伤患者认知功能变化的一项客观指标。

Relationship between P300 and intelligence quotient in severe head injury patients

Objective To explore the change of brain cognition function in severe head injury and the correlation between P300 in event-related potential(ERP) and intelligence quotient(IQ) .Methods Auditory P300 was measured and intelligence quotient was tested by Wechsler Adult Intelligence Scale Revised in China(WAIS-RC) in 40 severe head injury patients.Auditory P300 was measured in 40 normal healthy people as control group.Results The latencies of P300 in severe head injury patients group were longer than in control group.There was a significant difference between the two groups(P<0.01) .There were significant negative correlations between P300 latency and VIQ and FIQ respectively(r=-0.335,-0.344,P<0.05) .Conclusion ERP might be taken as an objective index for measuring the change of the brain cognition function in patients with severe head injury.