| mRNA和microRNA在机械性窒息死推断中的研究进展 |
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| 引用本文： | 潘 晖,吕叶辉,张 恒,陈 龙. mRNA和microRNA在机械性窒息死推断中的研究进展[J]. 中国法医学杂志, 2014, 0(2): 121-123 |
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| 作者姓名： | 潘 晖 吕叶辉 张 恒 陈 龙 |
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| 作者单位： | 复旦大学上海医学院法医学系; |
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| 基金项目： | 国家自然科学基金资助项目(81172896);国家自然科学基金资助项目(81373242) |
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| 摘 要： | 机械性窒息死的推断是法医学鉴定的难点之一。利用实时荧光定量PCR（fluorogenic quantitative RT-PCR,RT-qPCR）技术检测RNA表达水平变化规律,并据之推测机械性窒息死亡的原因,近年来已成为研究热点。本文对mRNA和microRNA（miRNA或miR）在机械性窒息死推断的研究文献进行复习综述,并重点探讨miRNA在该类死因推断中的应用,以期为机械性窒息死推断提供新的思路。
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| 关 键 词： | 法医病理学 机械性窒息 死亡原因 microRNA miR-210 |
Advances in applicability of mRNA and microRNA to estimate the cause of mechanical asphyxia death |
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| Pan Hui,Lv Yehui,Zhang Heng,Chen Long. Advances in applicability of mRNA and microRNA to estimate the cause of mechanical asphyxia death[J]. Chinese Journal of Forensic Medicine, 2014, 0(2): 121-123 |
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| Authors: | Pan Hui Lv Yehui Zhang Heng Chen Long |
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| Affiliation: | (Forensic Department of Shanghai Medical College, Fudan University, Shanghai 200032, China) |
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| Abstract: | Sometimes it is difficult in forensic science to estimate the cause of mechanical asphyxia death. The changes of RNA expression level detected by RT-qPCR could be used for the estimation,which has became a research focus recently. To provide novel perspectives for the future investigation,this review presents the advance of mRNA,and application of microRNA in particular,in deducing the cause of mechanical asphyxia death. |
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| Keywords: | forensic pathology mechanical asphyxia cause of death microRNA miR-210 |
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