A fatal methamphetamine poisoning associated with hyperpyrexia |
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Authors: | T. Kojima I. Une M. Yashiki J. Noda K. Sakai K. Yamamoto |
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Affiliation: | 1. Department of Legal Medicine, Hiroshima University School of Medicine, Hiroshima 734 Japan;1. Scientific Investigation Research Laboratory, Hiroshima Prefectural Police Headquarters, Hiroshima 730 Japan |
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Abstract: | After self-administration of 0.05g of methamphetamine hydrochloride intravenously on three occasions at intervals of 3h, a 25-year-old female methamphetamine abuser ingested approximately 1.5 g of methamphetamine hydrochloride, and was found dead 3–4 h later. Complete rigor mortis was observed 1–2 h after death and the rectal temperature was 38.4°C 3–4 h after death.Distribution of methamphetamine and amphetamine in the body was analyzed by chemical ionization mass fragmentography. Amphetamine/methamphetamine concentrations (μ mol/100 g) were in blood, in brain, in liver, in kidney, and in stomach contents. Total amount of methamphetamine hydrochloride in stomach contents was 11.6mg.Amphetamine in tissues was a metabolite of methamphetamine, and amphetamine in stomach contents resulted from excretion into saliva and gastric mucous excretion. With rectal temperature at death estimated at more than 41°C, it would seem that hyperpyrexia played an important role in causing death from methamphetamine poisoning. |
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Keywords: | Toxicology Rigor mortis Hyperpyrexia Methamphetamine Amphetamine Mass fragmentography |
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