Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers |
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| Authors: | Teresa Ju rez-Cedillo, Joaquí n Zu iga, Victor Acu a-Alonzo, Nonanzit P rez-Hern ndez, Jos Manuel Rodrí guez-P rez, Rodrigo Barquera, Guillermo J. Gallardo, Rosalinda S nchez-Arenas, Maria del Carmen Garcí a-Pe a, Julio Granados,Gilberto Vargas-Alarc n |
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| Affiliation: | Teresa Juárez-Cedillo, Joaquín Zuñiga, Victor Acuña-Alonzo, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, Rodrigo Barquera, Guillermo J. Gallardo, Rosalinda Sánchez-Arenas, Maria del Carmen García-Peña, Julio Granados,Gilberto Vargas-Alarcón, |
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| Abstract: | The 15 AmpFlSTR Identifiler loci D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA were analyzed in a sample of 378 unrelated individuals from Mexico City, Mexico. Significant deviations from HW equilibrium in 14/15 STR loci alleles were not detected. The D18S51 locus had the highest power of discrimination (0.970). Genetic admixture estimations revealed a 69% of Amerindian, 26% of European and 5% of African contribution. Comparative analyses between Mexicans and other neighboring populations reveal significant differences in genetic diversity. Our results are important for future comparative genetic studies in different Latin American ethnic groups, particularly Mexican Mestizos and Amerindians. They should also be helpful in genetics, population evolution, forensic and paternity testing. |
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| Keywords: | STR Frequency Mexicans Admixture estimation Population genetics |
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