| 一氧化氮对As_2O_3抑制马立克氏病病鸡肝肿瘤生长的影响 |
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| 引用本文： | 李金龙,国琳,刘晓瑛,张久丽,徐世文. 一氧化氮对As_2O_3抑制马立克氏病病鸡肝肿瘤生长的影响[J]. 中国兽医科学, 2010, 40(1) |
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| 作者姓名： | 李金龙 国琳 刘晓瑛 张久丽 徐世文 |
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| 作者单位： | 李金龙,国琳,徐世文(东北农业大学动物医学院,黑龙江,哈尔滨,150030);刘晓瑛(浙江省余姚市畜牧兽医局,浙江,余姚,315400);张久丽(东北农业大学动物医学院,黑龙江,哈尔滨,150030;黑龙江畜牧兽医职业学院,黑龙江,双城,150100) |
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| 基金项目： | 国家自然科学基金项目 |
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| 摘 要： | 人工复制鸡马立克氏病(MD)病例模型,通过腹腔注射三氧化二砷(As2O3,按体重3.0mg/kg),分别于注射后第35,40和45d观察了马立克氏病病鸡的病理学改变,并检测了肝肿瘤组织一氧化氮(NO)含量,总NOS(T-NOS)、诱导型NOS(iNOS)与构建型NOS(cNOS)活性和iNOSmRNA的表达水平,探讨了NO在As2O3抑制MD病鸡肝肿瘤生长中的作用。结果表明,MD病鸡肝肿瘤组织内的NO含量,T-NOS、cNOS及iNOS的活性增高,iNOSmRNA表达水平升高,As2O3能够显著抑制肝肿瘤生长,使肿瘤组织内的NO含量,T-NOS、cNOS及iNOS活性和iNOSmRNA表达水平降低,并呈现时间效应。证实NO在AsO抑制MD病鸡肝肿瘤生长中发挥着重要作用,这是AsO抗肿瘤作用的机制之一。
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| 关 键 词： | 鸡 马立克氏病 肝肿瘤 三氧化二砷 一氧化氮 |
Effect of nitric oxide on the As_2O_3 inhibition of the hepatic tumorous growth in chicken with Marek's disease |
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| LI Jin-long,GUO Lin,LIU Xiao-ying,ZHANG Jiu-li,,XU Shi-wen. Effect of nitric oxide on the As_2O_3 inhibition of the hepatic tumorous growth in chicken with Marek's disease[J]. Chinese Veterinary Science, 2010, 40(1) |
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| Authors: | LI Jin-long GUO Lin LIU Xiao-ying ZHANG Jiu-li XU Shi-wen |
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| Affiliation: | LI Jin-long1,GUO Lin1,LIU Xiao-ying2,ZHANG Jiu-li1,3,XU Shi-wen1(1.College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China,2.Animal Science , Veterinary Medicine Bureau,Yuyao 315400,3.Heilongjiang Vocational College of Animal Husb,ry , Veterinary Science,Shuangcheng 150100,China) |
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| Abstract: | A Marek's disease(MD) model was produced experimentally.Experimental chickens were injected with arsenic trioxide(As2O3)(3.0mg/kg B.W.) by intraperitoneal route.On days 35,40 and 45 post-injection,histopathological changes were observed,and the contents of nitric oxide(NO),the activities of total nitric oxide synthetase(T-NOS),constructional nitric oxide synthetase(cNOS) and inducible nitric oxide synthetase(iNOS) and the expression levels of iNOS mRNA were detected in the liver and tumorous tissues to expl... |
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| Keywords: | chicken Marek's disease hepatic tumor arsenic trioxide nitric oxide |
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