| 土鳖虫总生物碱对家兔心泵功能的影响 |
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| 作者姓名： | 龙子江 董宏超 盛炎炎 |
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| 作者单位： | 安徽中医学院药理教研室
(龙子江，董宏超)，安徽中医学院附属医院骨伤科(盛炎炎) |
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| 摘 要： | 实验结果表明:家兔静脉分别注射土鳖虫总生物碱5mg/kg、10mg/kg、15mg/kg、20mg/kg对兔心脏均呈明显的负性作用。即左室收缩压、左室舒张末期压力、左室压力最大速率均降低,右心房压力升高,心电图P-R传导见心率减慢,S-T段轻度缺血改变。当用至20mg/kg以上时,心电图出现明显的S-T段缺血改变,并有室性早搏。
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| 关 键 词： | 土鳖虫总生物碱 心脏泵功能 心力衰竭 |
Effects of Total Alkaloids from Eupolyphage Sinensis Walk on the Pump Function of Rabbits Heart |
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| Authors: | Long Zijiang |
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| Institution: | Long Zijiang |
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| Abstract: | The experimental results demonstrated that in anesthized
rabbits, total alkaloids from Eupolyphaga sinensis walk ( ESWA) used respectively 5 mg/kg, 10mg/kg, 15mg/kg, and 20mg/kg via iv, caused a significant decrease in LVSP, LVEDP and dp/dtmax, as well as in P-R interval and HR, but RVP increased and an ischemic degeneration found on S-T interval, which appeared particulally above 20mg/kg and at the sametime the vertricular premature beats seen too On ECG. |
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| Keywords: | Eupolyphaga sinensis walk alkaloids Cardial pump function Heart failure |
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