| 副黏病毒膜融合机制的研究进展 |
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| 引用本文： | 王帅,骆学农,窦永喜,张海瑞,才学鹏. 副黏病毒膜融合机制的研究进展[J]. 中国兽医科学, 2011, 0(12) |
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| 作者姓名： | 王帅 骆学农 窦永喜 张海瑞 才学鹏 |
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| 作者单位： | 中国农业科学院兰州兽医研究所家畜病原微生物国家重点实验室;山东亚太中慧集团; |
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| 基金项目： | 公益性农业行业研究专项(20103008); 甘肃省农业生物技术研究与应用开发项目(GNSW-2010-08) |
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| 摘 要： | 主要从副黏病毒膜融合的关键蛋白——附着蛋白和融合蛋白的结构与功能、附着蛋白的受体及其作用位点等方面论述了副黏病毒的膜融合机制,并讨论了基于不同附着蛋白受体的附着蛋白和融合蛋白相互作用的差异,以阐明基于不同附着蛋白受体膜融合的不同机制,并为进一步研究病毒入侵靶细胞的机理和该病毒的防治策略提供思路。
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| 关 键 词： | 副黏病毒 附着蛋白 融合蛋白 膜融合机制 |
Research advance in the mechanism of paramyxovirus membrane fusion |
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| WANG Shuai,LUO Xue-nong,DOU Yong-xi,ZHANG Hai-rui,CAI Xue-peng. Research advance in the mechanism of paramyxovirus membrane fusion[J]. Chinese Veterinary Science, 2011, 0(12) |
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| Authors: | WANG Shuai LUO Xue-nong DOU Yong-xi ZHANG Hai-rui CAI Xue-peng |
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| Affiliation: | WANG Shuai1,LUO Xue-nong1,DOU Yong-xi1,ZHANG Hai-rui2,CAI Xue-peng1(1.State Key Laboratory of Veterinary Etiological Biology/Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China,2.Shandong Yatai Zhonghui Group,Weifang 261061,China) |
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| Abstract: | Two paramyxovirus glycoproteins,the attachment protein and the fusion(F) protein,are key to the membrane fusion process.The structure and function of these two proteins,receptors and function sites of attachment proteins are discussed in this paper to review the mechanisms of paramyxovirus membrane fusion.And the mechanisims that are based on different receptors are also summarized by illustrating the different interaction between the two proteins.This preview provides some ideas for further study of virus ... |
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| Keywords: | paramyxovirus attachment protein fusion protein mechanism of membrane fusion |
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