| 二甲苯对小鼠卵巢组织损伤的研究 |
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| 引用本文： | 位兰,罗来强,张自强,李梦云,司立芳,李健,薛帮群. 二甲苯对小鼠卵巢组织损伤的研究[J]. 中国兽医科学, 2011, 0(9) |
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| 作者姓名： | 位兰 罗来强 张自强 李梦云 司立芳 李健 薛帮群 |
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| 作者单位： | 河南科技大学动物科技学院; |
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| 基金项目： | 河南科技大学博士科研启动基金项目(09001366) |
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| 摘 要： | 为了研究二甲苯对小鼠卵巢组织的损伤作用,以健康成年SD雌性小鼠作为实验动物,分3个试验组(低、中、高剂量组)和1个对照组,试验组腹腔注射不同剂量(按体重0.125、0.25、0.5mL/kg)的二甲苯,对照组每天腹腔注射生理盐水。采用石蜡切片和HE染色技术观察二甲苯染毒后小鼠卵巢组织结构的变化;采用分光光度法测定小鼠卵巢组织中超氧化物歧化酶(SOD)的活性和丙二醛(MDA)含量。结果表明,二甲苯染毒导致小鼠卵巢发生萎缩,中、高剂量组的卵泡内都有黑色颗粒,且随二甲苯剂量的增加其病理变化更加明显;中、高剂量组卵巢组织的SOD活性与对照组相比显著下降,而MDA含量显著升高。证实,二甲苯对卵巢组织具有明显的损伤作用,且表现出明显的剂量效应。
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| 关 键 词： | 二甲苯 小鼠 卵巢 超氧化物歧化酶 丙二醛 |
Damage in ovary tissue of mouse exposed to xylene |
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| WEI Lan,LUO Lai-qiang,ZHANG Zi-qiang,LI Meng-yun,SI Li-fang,LI Jian,XUE Bang-qun. Damage in ovary tissue of mouse exposed to xylene[J]. Chinese Veterinary Science, 2011, 0(9) |
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| Authors: | WEI Lan LUO Lai-qiang ZHANG Zi-qiang LI Meng-yun SI Li-fang LI Jian XUE Bang-qun |
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| Affiliation: | WEI Lan,LUO Lai-qiang,ZHANG Zi-qiang,LI Meng-yun,SI Li-fang,LI Jian,XUE Bang-qun(College of Animal Science and Veterinary Medicine,Henan University of Science and Technology,Luoyang 471003,China) |
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| Abstract: | In order to study the damage of xylene to the ovary tissue of mouse,healthy adult female SD mice were randomly divided into 3(high,middle,low dose) experimental groups and one control group.The mice in experimental groups were injected different volume of xylene(0.5,0.25,0.125 mL/kg) and the mice in the control group were injected intraperitoneally with normal saline solution every day.Histological structure of murine ovary under different xylene volume were observed by HE staining and paraffin section.The ... |
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| Keywords: | xylene mouse ovary SOD MDA |
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