Forensic application of chiral separation of amphetamine-type stimulants to impurity analysis of seized methamphetamine by capillary electrophoresis |
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Authors: | Iwata Yuko T Inoue Hiroyuki Kuwayama Kenji Kanamori Tatsuyuki Tsujikawa Kenji Miyaguchi Hajime Kishi Tohru |
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Affiliation: | National Research Institute of Police Science, Kashiwanoha, Kashiwa, Chiba, Japan. togawa@nrips.go.jp |
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Abstract: | The applicability of capillary electrophoresis (CE) with a UV detector using highly sulfated gamma-cyclodextrin as a chiral selector was examined for analysis of impurities in seized methamphetamine. Samples of methamphetamine-hydrochloride dissolved in water at a high concentration (20 mg/mL) were analyzed. Electrokinetic injection has an advantage over hydrodynamic injection for improving the detection of trace impurities. Small peaks of the precursor impurities, such as (1R,2S)-(-)-ephedrine and (1S,2S)-(+)-pseudoephedrine, were detected and quantified without extraction. The seized drugs could be classified into three groups based on the contents of the two impurities. |
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