复方守宫散辅助治疗晚期结直肠恶性肿瘤的疗效观察

目的 基于倾向性评分匹配法探讨复方守宫散辅助治疗晚期结直肠恶性肿瘤的疗效。方法 采用倾向性评分匹配法，将匹配成功的70例患者分为对照组（化学治疗）和观察组（复方守宫散联合化学治疗），每组35例；比较两组患者瘤体客观疗效［客观缓解率（objective response rate，ORR），疾病控制率（disease control rate，DCR）］、生活质量评分、免疫功能指标、安全性指标，并对生存期进行分析。结果 观察组ORR、DCR优于对照组（P＜0.05）；观察组患者治疗后功能维度（躯体功能、角色功能、情绪功能、认知功能、社会功能），症状领域（疲劳、疼痛、恶心呕吐）评分改善程度显著优于对照组（P＜0.05）；观察组患者血清CD4+T细胞、CD8+T细胞、自然杀伤细胞水平，CD4+/CD8+均显著高于对照组（P＜0.05）；治疗组患者总不良反应发生率显著低于对照组（P＜0.05）；观察组的中位无进展生存期显著高于对照组（P＜0.05），中位总生存期高于对照组（P＞0.05）。结论 相较于单纯化学治疗，复方守宫散与化学治疗联合应用能显著提高疗效，增强机体免疫力，改善晚期结直肠癌患者生活质量，降低化学治疗的毒性及不良反应，在一定程度上延长患者生存时间。

Therapeutic Efficacy of Compound Shougong Powder as an Adjuvant Therapy for Advanced Colorectal Cancer

Objective To investigate the efficacy of Compound Shougong Powder as an adjuvant therapy for advanced colorectal cancer based on propensity score matching. Methods Based on the propensity score matching method, 70 patients were divided into control group (chemotherapy) and observation group (Compound Shougong Powder combined with chemotherapy), with 35 patients in each group. The two groups were compared in terms of objective tumor response\objective response rate(ORR)and disease control rate (DCR)\], quality of life score, immune function parameters, safety indices, and survival time. Results The observation group had significantly better ORR and DCR than the control group (P<0.05). Compared with the control group after treatment, the observation group had significantly greater improvements in functional dimensions (physical function, role function, emotional function, cognitive function, and social role functioning) and symptom scores (fatigue, pain, nausea, and vomiting) (P<0.05).The observation group had significantly higher percentages of CD4+ T cells, CD8+ T cells, and natural killer cells and a significantly higher CD4+/CD8+ratio (P<0.05). Compared with the control group, the observation group had a significantly lower incidence rate of adverse events (P<0.05), a significantly higher median progression-free survival rate (P<0.05), and a higher overall survival rate (P>0.05). Conclusion Compared with chemotherapy alone, Compound Shougong Powder combined with chemotherapy can significantly improve clinical response, enhance immunity,improve the quality of life of patients with advanced colorectal cancer, reduce the toxicity and adverse effects of chemotherapy, and prolong survival time to a certain extent.