| 鱼胆中毒的实验病理研究 |
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| 引用本文： | 孙洪涛,黄光照,张益鹄,刘良,邓伟年. 鱼胆中毒的实验病理研究[J]. 中国法医学杂志, 1991, 0(1) |
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| 作者姓名： | 孙洪涛 黄光照 张益鹄 刘良 邓伟年 |
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| 作者单位： | 同济医科大学法医病理学教研究室 武汉(430030)(孙洪涛，黄光照，张益鹄，刘良)，同济医科大学法医病理学教研究室 武汉(430030)(邓伟年) |
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| 摘 要： | 40只Wistar 大鼠随机分为3个实验组和1个对照组。实验组分别以6. 9ml/kg、4. 6ml/kg 和2. 3ml/kg 剂量灌服草鱼胆汁。每3天一次,共5次。结果表明:实验大鼠肾近曲小管上皮细胞广泛变性坏死,其AKP 酶活性明显下降;血清BUN 显著增高。提示急性鱼胆申毒在病程迁延时主要损害肾脏,其死因为急性肾功能衰竭。本实验较成功地复制出鱼胆中毒的动物模型。
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| 关 键 词： | 鱼胆 鱼胆中毒 肾小管坏死 |
AN EXPERIMENTAL PATHOLOGICAL STUDY OF FISH BILE POISONING |
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| Sun Hongtao Huang Guangzhao Zhang Yigu Liu Liang Deng Weinian. AN EXPERIMENTAL PATHOLOGICAL STUDY OF FISH BILE POISONING[J]. Chinese Journal of Forensic Medicine, 1991, 0(1) |
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| Authors: | Sun Hongtao Huang Guangzhao Zhang Yigu Liu Liang Deng Weinian |
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| Abstract: | Fourty rats were randomly divided into three experimental groups and a controlgroup.Ctenopharyngodon Idellus bile was given by stomach administration in dosesof 6. 9ml/kg,4. 6ml/kg,and 2. 3ml/kg in the experimental groups respectively,onceevery three days.the experiment lasted for fifteen days.There were degenerationand necrosis of the proximal convoluted tubular epithelium of kidney of the experi-mental rats.The AKP enzyme activity in the kidney decreased and the serum BUNincreased markedly.It is suggested that fish bile poisoning mainly damaged rats'kidney.Acute renal failure was the major cause of death,we have successfullyreproduced the animal model of fish bile poisoning. |
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| Keywords: | Fish bile Fish bile poisoning Renal tubular epithelium necrosis |
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