HPLC-ESI-MS/MS determination of zuclopenthixol in a fatal intoxication during psychiatric therapy. |
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| Authors: | M Kollroser G Henning R Gatternig C Schober |
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| Institution: | Institute of Forensic Medicine, Karl-Franzens University Graz, Universitaetsplatz 4, A-8010 Graz, Austria. manfred.kollroser@kfunigraz.ac.at |
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| Abstract: | The first non-suicidal fatality due to intramuscular administration of Cisordinol (zuclopenthixol, ZPT) is described. A new, rapid, and sensitive method for the determination of ZPT in postmortem specimens has been developed. High performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was employed for drug confirmation and quantitation. Sample clean up was performed using a simple liquid-liquid extraction procedure. The postmortem concentration of ZPT in heart blood was 0.68 microg/ml. Furthermore, zotepine, carbamazepine, and chlorprotixene were detected in body fluids. The proposed method enables the unambiguous identification and quantitation of ZPT and other neuroleptic drugs in clinical and forensic specimens. |
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