| 奇正伤湿止痛膏对大鼠皮肤角质层影响的实验研究 |
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| 引用本文： | 谢平,谷素敏,杜亚豪,吴志宏,李汇华. 奇正伤湿止痛膏对大鼠皮肤角质层影响的实验研究[J]. 安徽中医药大学学报, 2010, 0(1): 41-43 |
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| 作者姓名： | 谢平 谷素敏 杜亚豪 吴志宏 李汇华 |
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| 作者单位： | [1]中国医学科学院基础医学研究所,北京100005 [2]北京协和医院,北京100005 |
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| 基金项目： | 国家科技支撑计划(2007BAI31B04) |
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| 摘 要： | 目的探讨奇正伤湿止痛膏用药期间和停止用药后对大鼠皮肤角质层超微结构的影响。方法选用10周龄Wistar大鼠，在其背部两侧皮肤涂抹含伤湿止痛膏药物的浸膏和不合药的对照膏剂，应用电子显微镜观察该药剂引起的皮肤角质层超微结构的变化。结果与对照膏剂比较，涂药4～12h后表皮角质层开始变薄，细胞间距增大，细胞结构变得比较疏松，外层细胞有脱落。1d后，角质层疏松减轻，细胞间距缩小。停药后第1天，表皮角质层细胞间距变小。停药3d后，表皮角质层已基本恢复正常。结论该膏剂主要通过降低皮肤角质层的屏障作用，促进药物透皮吸收效率。停止用药后表皮角质层变化可短时间内恢复正常。
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| 关 键 词： | 奇正伤湿止痛膏 皮肤 超微结构 透皮吸收 |
Effect of Qizheng Shangshi Zhitong Gao on Epidermal Ultrastructure of Rat Skin |
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| XIE Ping,GU Su-min,DU Ya-hao,WU Zhi-hong,LI Hui-hua. Effect of Qizheng Shangshi Zhitong Gao on Epidermal Ultrastructure of Rat Skin[J]. Journal of Anhui Traditional Chinese Medical College, 2010, 0(1): 41-43 |
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| Authors: | XIE Ping GU Su-min DU Ya-hao WU Zhi-hong LI Hui-hua |
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| Affiliation: | 1.Institute of Basic Medical Sciences;Chinese Academy of Medical Sciences;Beijing 100005;China;2.Peking Union Hospital;China |
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| Abstract: | Objective To investigate the effects of Qizheng Shangshi Zhitong Gao(QSZG),an external preparation of traditional Chinese medicine,on the ultrastructure of rat skin during medication and after discontinue medication.Methods Wistar rats of 10-12 weeks old were employed.The QSZG extracts and control extracts without QSZG were painted on the skin at two sides of the rat back.The ultrastructural changes of rat skin were examined by transmission electron microscopy.Results Four to twelve hours after external app... |
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| Keywords: | Qizheng Shangshi Zhitong Gao Skin Ultrastructure Transdermal absorption |
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