| 针刀松解法对第3腰椎横突综合征大鼠中枢cAMP、cGMP的远期影响 |
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| 引用本文： | 刘乃刚,郭长青,孙红梅,李晓泓,吴海霞,许红,卢婧,胡波,刘琳,岳利锋,陈占禄,朱汉章. 针刀松解法对第3腰椎横突综合征大鼠中枢cAMP、cGMP的远期影响[J]. 安徽中医药大学学报, 2010, 0(5) |
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| 作者姓名： | 刘乃刚 郭长青 孙红梅 李晓泓 吴海霞 许红 卢婧 胡波 刘琳 岳利锋 陈占禄 朱汉章 |
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| 作者单位： | 刘乃刚,郭长青,李晓泓,刘琳,朱汉章(北京中医药大学针灸推拿学院,北京,100029);孙红梅,吴海霞,许红,岳利锋(北京中医药大学基础医学院,北京,100029);卢婧,胡波(北京水利医院,北京,100036);陈占禄(北京中医药大学管理学院,北京,100029)? |
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| 基金项目： | :国家重点基础研究发展计划? |
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| 摘 要： | 目的 观察针刀松解法对第3腰椎横突综合征大鼠中枢环磷酸腺苷(cyclic adenosine monophosphate, cAMP)、环磷酸鸟苷(cyclic guanosine monophosphate, cGMP)含量的远期影响,探讨针刀松解法的长效镇痛机制. 方法 将28只SD大鼠随机分为正常组、模型组、电针组和针刀组,后3组复制模型,后两组再于模型复制后14 d分别给予电针和针刀松解治疗,连续治疗2周.模型复制后56 d采用断头法处死动物,快速取出腰段脊髓和下丘脑,采用放射免疫法检测腰段脊髓和下丘脑cAMP、cGMP含量. 结果 与正常组比较,模型组腰段脊髓、下丘脑中cAMP水平及下丘脑中cGMP水平显著升高(P<0.01);与模型组比较,电针组、针刀组腰段脊髓和下丘脑中cAMP水平显著下降(P<0.05,或P<0.01),而cGMP水平无显著性变化;与电针组比较,针刀组上述指标均无显著性变化. 结论 针刀松解法长效镇痛作用的发挥,可能与中枢cAMP含量的变化有关.
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| 关 键 词： | 第3腰椎横突综合征 针刀松解法 腰段脊髓 下丘脑 远期影响 |
Long-term Effect of Acupotomy Lysis on Levels of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate in Lumbar Spinal Cord and Hypothalamus in Rats with the Third Lumbar Vertebra Transverse Process Syndrome |
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| LIU Nai-gang,GUO Chang-qing,SUN Hong-mei,LI Xiao-hong,WU Hai-xi,XU Hong,LU Jing,HU Bo,LIU Lin,YUE Li-feng,CHEN Zhan-lu,ZHU Han-zhang. Long-term Effect of Acupotomy Lysis on Levels of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate in Lumbar Spinal Cord and Hypothalamus in Rats with the Third Lumbar Vertebra Transverse Process Syndrome[J]. Journal of Anhui Traditional Chinese Medical College, 2010, 0(5) |
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| Authors: | LIU Nai-gang GUO Chang-qing SUN Hong-mei LI Xiao-hong WU Hai-xi XU Hong LU Jing HU Bo LIU Lin YUE Li-feng CHEN Zhan-lu ZHU Han-zhang |
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| Affiliation: | LIU Nai-gang1,GUO Chang-qing1,SUN Hong-mei2,LI Xiao-hong1,WU Hai-xia2,XU Hong2,LU Jing3,HU Bo3,LIU Lin1,YUE Li-feng2,CHEN Zhan-lu4,ZHU Han-zhang1(1.College of Acupuncture , Moxibustion,Beijing University of Chinese Medicine,Beijing 100029,China,2.College of Preclinical Medicine,3.Beijing Hospital of Water Resources,Beijing 100036,4.College of Management,China) |
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| Abstract: | Objective To observe the long-term effect of acupotomy lysis on levels of cyclic adenosine monophosphate(cAMP),and cyclic guanosine monophosphate(cGMP) in lumbar spinal cord and hypothalamus in rats with the third lumbar vertebra transverse process syndrome,and to study the long-term analgesic effects of acupotomy lysis.Methods Twenty-eight SD rats were randomly divided into normal group,model group,electroacupunture(EA) group,and acupotomy lysis(AL) group.Rats in the last 3 groups were induced to the model... |
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| Keywords: | cAMP cGMP |
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