| 川芎嗪口服油包油微乳的研制及大鼠体内药物代谢动力学研究 |
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| 引用本文： | 完茂林,刘子荣,桂双英,鲁传华,林腾,王蕾. 川芎嗪口服油包油微乳的研制及大鼠体内药物代谢动力学研究[J]. 安徽中医药大学学报, 2011, 30(2): 60-64 |
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| 作者姓名： | 完茂林 刘子荣 桂双英 鲁传华 林腾 王蕾 |
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| 作者单位： | 安徽中医学院药学院,安徽,合肥,230031;安徽中医学院药学院,安徽,合肥,230031;安徽中医学院药学院,安徽,合肥,230031;安徽中医学院药学院,安徽,合肥,230031;安徽中医学院药学院,安徽,合肥,230031;安徽中医学院药学院,安徽,合肥,230031 |
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| 基金项目： | 安徽省2008年度科技计划,安徽中医学院自然科学研究基金 |
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| 摘 要： | 目的 制备川芎嗪口服油包油(oil/oil, O/O)微乳,提高川芎嗪口服生物利用度.方法 在本课题组前期对O/O型非水微乳所做的共性构建的基础上,将川芎嗪制成川芎嗪O/O型口服微乳制剂,研究其在大鼠体内的药物代谢动力学特点.结果制备的川芎嗪O/O型口服微乳平均粒径为48.2 nm,基本成球形,大小分布较为均匀;川芎嗪...
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| 关 键 词： | 川芎嗪 油包油 微乳 药物代谢动力学 生物利用度 |
Preparation of Oral Tetramethylpyrazine Oil/Oil Microemulsion and Its Pharmacokinetics in Rats |
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| WAN Mao-lin,LIU Zi-rong,GUI Shuang-ying,LU Chuan-hu,LIN Teng,WANG Lei. Preparation of Oral Tetramethylpyrazine Oil/Oil Microemulsion and Its Pharmacokinetics in Rats[J]. Journal of Anhui Traditional Chinese Medical College, 2011, 30(2): 60-64 |
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| Authors: | WAN Mao-lin LIU Zi-rong GUI Shuang-ying LU Chuan-hu LIN Teng WANG Lei |
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| Affiliation: | WAN Mao-lin,LIU Zi-rong,GUI Shuang-ying,LU Chuan-hua,LIN Teng,WANG Lei(Department of pharmacy,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China) |
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| Abstract: | Objective To improve the oral bioavailability of Tetramethylpyrazine(TMP) by preparing oral TMP oil/oil(O/O) emulsion.Methods Based on the common building of the non-water O/O type microemulsion in early study,oral TMP O/O type microemulsion had been prepared,and its pharmacokinetics characteristics in rats had also been studied.Results The mean diameter of oral TMP O/O type microemulsion was 48.2 nm,which was basically spherical and uniform distribution.The relative bioavailability between oral microemulsi... |
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| Keywords: | tetramethylpyrazine oil/oil microemulsion pharmacokinetics bioavailability. |
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