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Correlations Among the HLA-DQB1 Alleles and Suicidal Behavior |
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| Authors: | Horea V. Matei Ph.D. Mihaela L. Vică Ph.D. Irina Ciucă M.D. Horia G. Coman Ph.D. Gheorghe Z. Nicula Ph.D. Costel V. Siserman Ph.D. |
| Affiliation: | 1. Department of Cell and Molecular Biology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 6 Pasteur Street, 400 349 Cluj-Napoca, Romania Legal Medicine Institute Cluj-Napoca, 3-5 Clinicilor Street, 400 006 Cluj-Napoca, Romania;2. Department of Cell and Molecular Biology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 6 Pasteur Street, 400 349 Cluj-Napoca, Romania;3. Department of Medical Psychology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 43 Victor Babeș Street, 400 012 Cluj-Napoca, Romania;4. Legal Medicine Institute Cluj-Napoca, 3-5 Clinicilor Street, 400 006 Cluj-Napoca, Romania Department of Legal Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400 006 Cluj-Napoca, Romania |
| Abstract: | Suicide is a worldwide health problem with multiple causes, including genetic factors. The major histocompatibility complex (MHC) is represented by an assembly of gene encoding the human leukocyte antigen (HLA). The purpose of our study was to determine associations between the HLA profiles and predisposition for suicidal behavior. We harvested blood samples from persons with history of suicidal attempts (case group) and persons never exhibiting such behavior (control group). The DNA was extracted and amplified via polymerase chain reaction (PCR) to determine the HLA-DQB1 profiles. Statistical data processing was performed with the Epi Info program. We found that the presence of the HLA-DQB1*02 allele increases the risk of suicidal behavior, while HLA-DQB1*05 alleviates such risk. The genotype that presented the most increased risk for suicidal behavior was found to be HLA-DQB1*02/HLA-DQB1*03. Our study has demonstrated the presence of several associations between HLA profiles and suicidal behavior. |
| Keywords: | forensic science DNA typing human leukocyte antigen DQB1 suicide polymerase chain reaction genotype |