免疫佐剂的作用机制及其应用

从抗原微粒化佐剂(如不溶性铝盐胶体、免疫刺激复合物、脂质体)、缓慢释放抗原佐剂(如油乳佐剂、抗原的微型包囊)、微生物佐剂(如细菌毒素、短小棒状杆菌菌苗、分枝杆菌及其成分、肽聚糖)、分子佐剂(如细胞因子、C3d分子、共刺激分子、超抗原、热休克蛋白、CpG序列)和其他佐剂(如维生素E、硒、抗生素类、拟胸腺素药物、蜂胶、中药多糖)等几方面阐述了免疫佐剂的性质、作用机制及应用的研究现状,为免疫佐剂的临床应用和进一步研制提供了参考资料。

Recent advances in the mechanisms and application of immunoadjuvants

Recent advances were reviewed in the mechanisms and application of immunoadjuvant,including partial antigen adjuvants(insoluble aluminium salt colloidal,immunostimulating complex and liposome),prolonged release antigen adjuvants(oil-aqueous emulsion and encapsulated antigen),microbial adjuvants(bacteriotoxin,vaccine Corynebacter parvum,Mycobacterium and their metabolites,peptidoglycan),molecular adjuvants(cytokines,C3d molecules,costimulatory molecules,super-antigen,heat shock protein and CpG motif) and other adjuvants(vitamin E,selenium,antibiotics,thymosin-like drugs,propolis and polysaccharides),which could provide important references for the clinic application and further development of immunoadjuvants.