| 利用多体素氢质子磁共振波谱推测死亡时间 |
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| 作者姓名： | Yang TT Li ZW Liu L Zheng N |
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| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北,武汉,430030
2. 华中科技大学同济医学院附属同济医院放射科,湖北,武汉,430030 |
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| 摘 要： | 目的利用多体素氢质子磁共振波谱推断死亡时间。方法选取12只白兔,利用多体素磁共振波谱测定死后0.5、1、2、4、6、8、12、16、24h脑内N-乙酰天冬氨酸、胆碱复合物及磷酸肌酸和肌酸的代谢值。结果在死后24h内Naa/Cr、Naa/Ch随死亡时间的延长而降低;Ch/Cr先升高再下降,然后持续升高。结论经多体素质子磁共振研究,Naa/Cr、Naa/Ch、Ch/Cr死后改变呈现一定规律,可用于推断死亡时间。
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| 关 键 词： | 法医病理学 死亡时间 磁共振波谱分析 |
| 文章编号： | 1004-5619(2007)06-0405-04 |
| 修稿时间： | 2007年6月9日 |
Estimation of postmortem interval with multivoxel-voxel proton 1H-MR spectroscopy |
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| Yang TT,Li ZW,Liu L,Zheng N.Estimation of postmortem interval with multivoxel-voxel proton 1H-MR spectroscopy[J].Journal of Forensic Medicine,2007,23(6):405-408. |
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| Authors: | Yang Tian-Tong Li Zhen-Wei Liu Liang Zheng Na |
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| Institution: | Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yttwowo@163.com |
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| Abstract: | Objective The purpose of our study was to evaluate the postmortem interval with multi-voxel 1H-MR spectroscopy. Methods Twelve healthy rabbits were studied and the quantities of N-acetylaspartate, total choline, phosphocreatine and creatine were measured by 1H-MR spectroscopy after death at 0.5, 1, 2, 4, 6, 8, 12, 16, and 24 h. Results The levels of Naa/Cr and Naa/Ch decreased following death, while the level of Ch/Cr increased initially and then decreased following death. Conclusion Multi-voxel proton MR spectroscopy for Naa/Cr and Ch/Cr metabolic ratio could be used in future postmortem interval studies. |
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| Keywords: | forensic pathology postmortem interval magnetic resonance spectroscopy |
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