| Connexin43与心肌缺血相关性研究 |
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| 作者姓名： | Chen Y Hu H Liao Z |
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| 作者单位： | 四川大学华西基础医学与法医学院,四川,成都,610041 |
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| 摘 要： | 目的探讨Cx43在急性心肌缺血时缺血时间与表达量的相关性。方法结扎兔左冠状动脉造成急性心肌缺血模型,于结扎后不同时间取左心室前壁心肌。用HBFP染色定位心肌缺血区域,以SP法显示Cx43的表达,通过图像分析系统分析采集IOD值,分析不同时间急性心肌缺血与Cx43的IOD值。结果急性心肌缺血时间与Cx43的表达呈负相关。即随着缺血时间延长,缺血面积增加,Cx43的表达呈下降趋势,两者相关性有统计学意义。结论兔心肌Cx43的表达,与缺血时间呈负相关。
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| 关 键 词： | Cx43 HBFP 急性心肌缺血 相关性 |
| 文章编号： | 1004-5619(2004)01-0007-02 |
| 修稿时间： | 2002年6月16日 |
Correlation study between the connexin43 and the myocardial ischemia in rabbit |
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| Chen Y,Hu H,Liao Z.Correlation study between the connexin43 and the myocardial ischemia in rabbit[J].Journal of Forensic Medicine,2004,20(1):7-8. |
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| Authors: | Chen Yang Hu Huazi Liao Zhigang |
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| Institution: | West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. chy5454@163.com |
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| Abstract: | Objective To study the co rr elation between quantity of the connexin43express and ischemia time in rabbit.Me thods Left coronary arteries were ligated to create early myocardial ischemia du ring dis-tinct time,HBFP staining was used in the ischemia spot and SP method was use d to show the expression of connexin43and the ischemia area were measured by the computer image analysis.Results Negative correlation was observed between the c onnexin43quantity and the ischemia time.The significant was dif-ference.Conclusion With ischemia time raised,expression of connexin43was des cented. |
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| Keywords: | Cx43 HBFP acute myocardial ischemia linear correlation |
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