| 胆囊收缩素(CCK)在冠状动脉粥样硬化斑块中的表达 |
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| 引用本文： | 马丽琴,来茂德,周韧,朱有法. 胆囊收缩素(CCK)在冠状动脉粥样硬化斑块中的表达[J]. 中国法医学杂志, 2010, 25(4): 239-241 |
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| 作者姓名： | 马丽琴 来茂德 周韧 朱有法 |
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| 作者单位： | 1. 浙江大学医学院病理与法医学研究所,浙江,杭州,310058;浙江大学司法鉴定中心,浙江,杭州,310058
2. 浙江大学医学院病理与法医学研究所,浙江,杭州,310058 |
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| 基金项目： | 浙江省教育厅资助项目，浙江大学医学部"中央高校基本科研业务费专项资金"青年科研创新专项 |
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| 摘 要： | 目的揭示胆囊收缩素(CCK)在冠状动脉粥样硬化斑块中的表达情况,以进一步探讨CCK在动脉粥样硬化形成过程中的作用。方法选用100例35～92岁男性尸检冠状动脉粥样硬化标本,分为粥样硬化Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组,同时设正常对照组,用免疫组化技术进行检测。结果对照组CCK呈阴性表达,而冠状动脉粥样硬化组呈阳性表达(P0.01),Ⅰ～Ⅱ级组与Ⅲ～Ⅳ级组之间CCK表达无显著差异(P0.05)。结论 CCK在冠状动脉粥样硬化斑块中的有表达,但不随粥样硬化斑块程度的变化而变化。
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| 关 键 词： | 法医病理学 胆囊收缩素（CCK） 免疫组织化学染色 冠状动脉 粥样硬化斑块 |
The expression of CCK in atherosclerotic plaque of coronary artery of autopsy |
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| MA Liqin,LAI Maode,ZHOU Ren,ZHU Youfa. The expression of CCK in atherosclerotic plaque of coronary artery of autopsy[J]. Chinese Journal of Forensic Medicine, 2010, 25(4): 239-241 |
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| Authors: | MA Liqin LAI Maode ZHOU Ren ZHU Youfa |
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| Affiliation: | 1.Research Institute of Pathology and Forensic Medicine of Zhejiang University medical college,Hangzhou 310058,China;2.Forensic Science Identification Center of Zhejiang University,Hangzhou 310058,China |
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| Abstract: | Objective To reveal the expression of CCK in coronary artery atherosclerotic plaques,and further explore the role of CCK in the formation of coronary atherosclerosis.Methods 100 autopsy specimens of coronary atherosclerosis(35～92 years old male)were divided into atherosclerosis-level I～II and III～IV groups,and normal control group.The immunohistochemical technology was adopted.Results The expression of CCK is positive in atherosclerotic groups compare with the negative in control group(P<0.01).But it has no significant differences between I～II and III～IV groups(P>0.05).Conclusion There exists an expression of CCK in coronary atherosclerotic plaque,and dosen't change with the degrees of atherosclerotic plaque. |
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| Keywords: | forensic pathology CCK immunohistochemistry staining coronary artery atherosclerotic plaque |
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