| 纤维连接蛋白在多器官功能不全综合征的心肺肾组织中的表达 |
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| 引用本文： | 罗思敏,竞花兰,吴日芸,李艳容,陈灿球,贾宵. 纤维连接蛋白在多器官功能不全综合征的心肺肾组织中的表达[J]. 中国法医学杂志, 2002, 17(3): 131-133 |
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| 作者姓名： | 罗思敏 竞花兰 吴日芸 李艳容 陈灿球 贾宵 |
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| 作者单位： | 1. 中山大学法医病理教研室,广东,广州,510080
2. 清远市公安局刑警支队,广东,清远,511500 |
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| 基金项目： | 卫生部基金资助,基金编号94—1—101。 |
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| 摘 要： | 目的 探讨纤维连接蛋白(FN)在多器官功能不全综合征(MODS)中的表达规律及其意义。方法 应用免疫组化技术,对20例MODS和12例非MODS死亡标本的心、肺、肾组织的FN进行检测。结果 非MODS的心、肺、肾组织FN表达多为阳性或强阳性,MODS多为弱阳性或阳性;两组间比较,差异显著(P<0.01)。结论 MODS时组织中FN降低,FN降低可能导致MODS。
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| 关 键 词： | 法医病理学 多器官功能不全综合症(MODS) 免疫组化 纤维连接蛋白(FN) |
| 文章编号： | 1001-5728(2002)03-0131-03 |
| 修稿时间： | 2001-11-01 |
Study on the expression of fibronectin in heart, lung and kidney in case of multiple organ dysfunction syndrome |
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| LUO Simin,JING Hualan,WU Riyun,et al.. Study on the expression of fibronectin in heart, lung and kidney in case of multiple organ dysfunction syndrome[J]. Chinese Journal of Forensic Medicine, 2002, 17(3): 131-133 |
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| Authors: | LUO Simin JING Hualan WU Riyun et al. |
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| Affiliation: | LUO Simin,JING Hualan,WU Riyun,et al. Department of forensic pathology,Zhongshan University,Guangzhou 510080) |
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| Abstract: | Objective To study the relationship between the expression of FN in heart, lung and kidney and the mechanism of multiple organ dysfunction syndrome (MODS). Method The Fn in heart, lung and kidney in 20 autopsy cases of MODS were studied immunohistochemically by using anti-FN as the first antibodies. Results The expression of FN in the MODS group were significantly decreased as compared with the control group (P<0.01). Conclusion The expression of FN decreased in MODS. It might be one of the mechanism of MODS. |
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| Keywords: | Forensic pathology Multiple organ dysfunction syndrome (MODS) Immunohistoche- mistry Fibronectin (FN) |
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