Explanation of nonspecific serologic reactions in decomposed bone tissue |
| |
Authors: | R Hauser B Brinkmann |
| |
Affiliation: | Institut für Rechtsmedizin, Medizinische Akademie Gdánsk, Polen. |
| |
Abstract: | Bone fragments were stored in water for 2 years at room temperature and investigated serologically using the following methods: Absorption-elution, extraction of blood group substances and immunohistochemistry (PAP). All 3 methods gave essentially specific results for fresh bone tissue but with putrid bone tissue unspecific reactions were found predominantly with the absorption-elution and PAP techniques. In contrast, more specific reactions were obtained from the extracts although they were much weaker. From this it can be concluded that pure physical binding plays a substantial role in the unspecific reaction between antibodies and bone material. It is suggested that the relevant physical properties are altered by putrification. |
| |
Keywords: | |
|
|