| 实验性大鼠脑震荡后Bcl-2的表达 |
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| 引用本文： | Zhu XY,Wang F,Fang WH,Wu MW. 实验性大鼠脑震荡后Bcl-2的表达[J]. 法医学杂志, 2007, 23(1): 18-19,F0002 |
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| 作者姓名： | Zhu XY Wang F Fang WH Wu MW |
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| 作者单位： | 皖南医学院法医系,安徽,芜湖,241001 |
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| 摘 要： | 目的观察实验性大鼠脑震荡后Bcl-2表达的变化规律。方法应用免疫组织化学方法检测大鼠脑震荡后不同时间大脑皮层、脑干和小脑等脑区内Bcl-2表达的变化规律进行研究。结果对照组大鼠未见Bcl-2蛋白的表达。脑震荡组损伤后1h组可在神经细胞内观察到少量Bcl-2蛋白的表达,4d达到高峰,8d和16d,Bcl-2蛋白表达随后逐渐下降。结论Bcl-2的检测可能成为脑震荡的诊断和脑损伤时间推断的一个敏感指标。
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| 关 键 词： | 脑震荡 Bcl-2 免疫组织化学 |
| 文章编号： | 1004-5619(2007)01-0018-02 |
| 修稿时间： | 2006-05-19 |
Bcl-2 expression following the brain concussion in rats |
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| Zhu Xu-yang,Wang Feng,Fang Wei-hua,Wu Mao-wang. Bcl-2 expression following the brain concussion in rats[J]. Journal of Forensic Medicine, 2007, 23(1): 18-19,F0002 |
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| Authors: | Zhu Xu-yang Wang Feng Fang Wei-hua Wu Mao-wang |
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| Affiliation: | Department of Forensic Medicine, Wannan Medical College, Wuhu 241001, China. |
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| Abstract: | Objective To evaluate the expression of Bcl-2 protein after brain concussion.Methods Expression levels of Bcl-2 protein in cortex,pontine and cerebellum of rats were investigated using immunohistochemistry.Results There was no expression of Bcl-2 protein in control group seen.The expression of Bcl-2 protein in brain concussion groups was detected at 1hour,and the expression level reached its peak 4 days after the concussion and then declined gradually.Conclusion Our findings suggest that the detection of Bcl-2 protein could be an indicator for diagnosis of brain concussion and for estimation of the post injury time interval. |
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| Keywords: | brain concussion Bcl-2 immunohistochemistry |
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