骨生丸治疗股骨颈骨折后早期股骨头坏死的实验研究

目的：探讨中药制剂骨生丸治疗股骨颈骨折后早期股骨头坏死的作用机制。方法：按照Kenzora方法,复制大白兔凤骨颈骨折后早期股骨头坏死动物模型,灌药4周后断头取血,取出股容、血沉、还原粘度、聚集指数及纤维蛋白等血液流变性指标。结果：骨生丸能够有效地降低空骨陷窝率,改善血液流变性状态。结论：骨生丸通过逆转股骨颈骨折后早期股骨头坏死的股骨头缺血状态,促进股骨头坏死修复而起治疗作用。

EXPERIMENTAL RESEARCH ON THERAPEUTIC EFFECT OF GUSHENG PILL ON FEMORAL HEAD NECROSIS AT EARLY STAGE AFTER FEMORAL NECK FRACTURE

Objective:To probe into the mechanism of Gusheng Pill,a traditional Chinese preparation,in the treatment of femoral head necrosis at the early stage after femoral neck fracture.Method:White rabbits'' models of femoral head necrosis at the early stage was made according to Kenzora''s method.The rabbits in treatment group were fed with GSP for 4 weeks,then,were killed by decapitation.Rabbit femoral heads were taken out and the mean bone lacuna rate was observed under microscope.The whole blood viscosity,plasma ratio viscosity,hematocrit,blood sedimentation,reduction viscosity,collecting exponent and fibrin were assayed with radioimmunoassay.Rusult:GSP had good effect on decreasing mean bone lacuna rate and improving the state of blood rheology.Conclusion:GSP has the therapeutic effect by reversing the ischemic state of femoral head and promoting the renovation of femoral head necrosis.