| 灯盏花注射液对脑缺血再灌注损伤的保护作用 |
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| 作者姓名： | 曲友直 高国栋 赵燕玲 夏天 赵文英 |
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| 作者单位： | [1]中国人民解放军第四军医大学唐都医院神经外科，陕西西安710038 [2]中国人民解放军第四军医大学西京医院 |
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| 摘 要： | 目的：研究灯盏花注射液对避灶性脑缺血再灌注损伤的保护作用及机制。方法：采用大鼠局灶性脑缺血再灌注模型，观察灯盏花注射液对血清胞浆酶及fos蛋白表达的影响。结果：脑缺血现后血清胞浆酶含量及foa蛋白表达显增加（P＜0．01）；灯花注射液可明显降低脑缺血再灌注后血清胞浆酶含量，下调fos蛋白的高表达（P＜0．01），结论：灯盏花注射液对脑缺血再灌注损伤有保护作用，其机制可能与其犯罪 清胞浆酶及下调fos蛋白高表达有关。
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| 关 键 词： | 灯盏花注射液 脑缺血 再灌注损伤 血清胞浆酶 fos蛋白 治疗 保护作用 |
| 修稿时间： | 2001/2/28 0:00:00 |
PROTECTIVE EFFECTS OF ERIGERON INJECTION ON CEREBRAL ISCHEMIC AND REPERFUSION INJURY |
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| Authors: | QU You-zhi ZHAO Yan-ling ZHAO Wen-ying GAO Guo-dong XIA Tian |
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| Abstract: | Objective:To study the protective effects of erigeron injection(EI) on cerebral ischemic and reperfusion injury.Method:Animal model of focal cerebral ischemia and reperfusion injury was established in SD rats and the effects of EI on serum cytosolic enzymes,expression of fos protein were observed.Result:After cerebral ischemia and reperfusion injury,serum cytosolic enzymes,expression of fos protein increased significantly(P<0.01).EI could decrease the contents of serum cytosolic enzymes and high expression of fos protein(P<0.01).Conclusion:EI has the neuroprotective effects on cerebral ischemia and reperfusion injury.The mechanism may relate with EI decreasing serum cytosolic enzymes and inhibiting expression of fos protein. |
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| Keywords: | Erigeron injection Cerebral ischemia and reperfusion injury Cytosolic enzymes fos protein |
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