| 有机磷农药中毒的人体血液致死浓度探讨 |
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| 作者姓名： | Bu J Yan L Chen Y Chu JX Xie XF Chen TP |
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| 作者单位： | 1. 司法部司法鉴定科学技术研究所,
2. 浙江省人民检察院检察技术研究所; |
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| 摘 要： | 对 4年间 6家医院所有门急诊有关敌敌畏、甲胺磷、乐果三种有机磷农药中毒病例进行了调查分析。运用气相色谱法对其血液中的浓度进行测定。采用 Bliss法,计算其死亡率和昏迷率的加权直线回归方程,并获得其经救治后血液半数致死浓度 LC50、半数致昏迷浓度 CC50。综合文献和临床实践,认为及时的救治对中毒病例的治疗转归有较大影响,其自然的血液半数致死浓度应在经救治的半数致死浓度 LC50和半数致昏述浓度之间。综合半数致死浓度和半数致昏迷浓度,计算其自然的半数致死浓度 LCe50值。
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| 关 键 词： | 有机磷农药 血液检查 死亡率 半数致死量 半数致死浓度 |
| 文章编号： | 1004-5619（2001）01-0021-04 |
| 修稿时间： | 1999年12月17 |
Prospective study of lethal blood concentration of organophosphorous in humans |
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| Bu J,Yan L,Chen Y,Chu JX,Xie XF,Chen TP.Prospective study of lethal blood concentration of organophosphorous in humans[J].Journal of Forensic Medicine,2001,17(1):21-24. |
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| Authors: | Bu J Yan L Chen Y Chu J X Xie X F Chen T P |
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| Institution: | Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063. |
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| Abstract: | Total cases of organophosphorous (dichlorvos, methamidophos, dimethoate) poisoning outpatients from six hospitals during four years were collected consecutively for lethal blood concentration study. Blood samples were detected with gas chromatography. The probabilities of death, coma were analyzed with Bliss method and their linear regressive equations of probit were obtained respectively, their 50% lethal concentrations (LC50) and 50% coma concentrations(CC50) were calculated by the formulas above. As the death rate was influenced by therapy, its natural death probability has been discussed and estimated their natural LC50 were between the LC50 and CC50 themselves. Combined LC50 and CC50, their natural LC50 were calculated. |
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| Keywords: | organophosphorous Blood gas chromatography LC50 CC50 |
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