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| LC／MS／MS法测定生物组织中百草枯 | |
| 引用本文： | 王朝虹,王忠,刘学俊,王志萍. LC／MS／MS法测定生物组织中百草枯[J]. 中国法医学杂志, 2008, 23(2): 114-116 |
| 作者姓名： | 王朝虹 王忠 刘学俊 王志萍 |
| 作者单位： | 1. 公安部物证鉴定中心,北京,100038 2. 三亚市公安局,海南,三亚,572000 3. 天津市公安局宝坻分局刑侦支队,天津,301800 |
| 摘 要： | 目的建立LC／MS／MS检测生物体液中百草枯方法。方法弱阳离子交换固相萃取小柱提取剂，应用LC／MS／MS法对生物样品中百草枯进行定性定量分析。结果经该方法测得百草枯的最小检出限为10ng／ml血（S／N≥3），线性范围为0．02～20μg／ml。结论该方法快速、灵敏、准确，适用于生物检材中百草枯的分析。 |
| 关 键 词： | 法医毒物分析 百草枯 固相萃取 液相色谱-质谱联用 |
| 文章编号： | 1002-5728(2008)01-0114-03 |
| 修稿时间： | 2007-01-31 |
Detection of paraquat in biological tissues by LC/MS/MS/ |
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| WANG Zhao-hong,WANG Zhong,LIU Xue-jun,et al.. Detection of paraquat in biological tissues by LC/MS/MS/[J]. Chinese Journal of Forensic Medicine, 2008, 23(2): 114-116 | |
| Authors: | WANG Zhao-hong WANG Zhong LIU Xue-jun et al. |
| Affiliation: | WANG Zhao-hong,WANG Zhong,LIU Xue-jun,et al.Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China |
| Abstract: | Objective A LC/MS/MS method is developed for determination of paraquat in biological tissue.Methods The samples were pretreated with solid phase extraction using Oasis WCX cartridges and separated with HPLC,paraquat could be identified by LC/MS/MS.Result Calibration curves were linear on injection of amounts ranging from 0.02～20μg/ml and the limit of detection was 10ng/ml(S/N≥3).Conclusion The described menthod was proved to be sensitive,rapid and accurate,it will be applied in identification and determination of paraquat in biological tissues. |
| Keywords: | Forensic toxicologcal analysis Paraquat Solid phase extraction LC/MS/MS |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |