An improved method for complement subcomponent C1R typing |
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| Authors: | M I Kamboh R E Ferrell |
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| Affiliation: | Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA. |
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| Abstract: | An improved method has been developed for the reliable classification of different C1R genetic variant forms from human serum or plasma. The method combines the use of neuraminidase-digested samples followed by monodimensional isoelectric focusing in the pH range 5 to 8 followed by immunoblotting. The method yields a simple pattern, with one major band in homozygote and two major bands in heterozygote cases. |
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