| 犬细小病毒病基因工程疫苗的研究进展 |
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| 引用本文： | 徐进,孙世琪,曹随忠,孙德惠,郭慧琛. 犬细小病毒病基因工程疫苗的研究进展[J]. 中国兽医科学, 2012, 0(5): 541-544 |
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| 作者姓名： | 徐进 孙世琪 曹随忠 孙德惠 郭慧琛 |
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| 作者单位： | 中国农业科学院 兰州兽医研究所 家畜疫病病原生物学国家重点实验室;四川农业大学动物医学院动物疫病与人类健康四川省重点实验室 |
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| 基金项目： | 甘肃省科技重大专项(1102NKDA033,1102NKDA034);国家自然科学基金项目(31100688,31101838);甘肃省国际科技合作计划项目(1104WCGA185) |
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| 摘 要： | 从犬细小病毒病亚单位疫苗、表位疫苗、核酸疫苗、活载体疫苗等方面,论述了近年来国内外在犬细小病毒病新型疫苗研究方面的新进展,并对各种新型疫苗的优缺点及应用前景进行了讨论,为犬细小病毒病新型疫苗的研制提供理论基础。提出各种犬细小病毒病基因工程疫苗互有优劣,可以通过技术手段采用不同种类的新型疫苗的交叉组合、免疫原的集成使用等研制出更理想、更有效的疫苗。
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| 关 键 词： | 犬细小病毒 疫苗 基因工程 进展 |
Progress in genetic engineering vaccines against canine parvovirus |
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| XU Jin,SUN Shi-qi,CAO Sui-zhong,SUN De-hui,GUO Hui-chen. Progress in genetic engineering vaccines against canine parvovirus[J]. Chinese Veterinary Science, 2012, 0(5): 541-544 |
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| Authors: | XU Jin SUN Shi-qi CAO Sui-zhong SUN De-hui GUO Hui-chen |
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| Affiliation: | 1(1.State Key Laboratory of Veterinary Etiological Biology/Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China;2.Key Laboratory of Animal Diseases and Human Health of Sichuan Province/College of Veterinary Medicine,Sichuan Agricultural University,Ya’an 625014,China) |
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| Abstract: | To provide the theoretical references for the development of novel vaccine against canine parvovirus infection,researches on subunit vaccine,epitope vaccine,DNA vaccine and live vector vaccine against canine parvovirus infection in recent years were reviewed and discussed.The advantages and disadvantages of different vaccines in application were compared and highlighted.It suggested that there are pros and cons in different genetical engineering vaccines.It would be the best to develop the more effective and ideal novel vaccine by combining with the different vaccine style or using more and stronger immunogens. |
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| Keywords: | canine parvovirus vaccine genetic engineering progress |
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