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| 应用常染色体STR基因座共有等位基因数判别全同胞关系 | |
| 引用本文： | 赵书民,李成涛,张素华,李莉,林源,阙庭志. 应用常染色体STR基因座共有等位基因数判别全同胞关系[J]. 法医学杂志, 2009, 25(4): 267-270. DOI: 10.3969/j.issn.1004-5619.2009.04.008 |
| 作者姓名： | 赵书民 李成涛 张素华 李莉 林源 阙庭志 |
| 作者单位： | 1. 司法部司法鉴定科学技术研究所,上海市法医学重点实验室,上海,200063 2. 司法部司法鉴定科学技术研究所,上海市法医学重点实验室,上海,200063;复旦大学,生命科学学院,上海200433 3. 苏州大学,医学部法医学系,江苏,苏州,215123 |
| 基金项目： | 中央级科研院所社会公益研究项目 |
| 摘 要： | 目的建立基于常染色体STR基因座共有等位基因数的全同胞关系判别标准。方法根据280对全同胞及2003对无关个体Identifiler系统15个STR基因座的分型结果,对15个STR基因座的共有等位基因数（S15）和全同胞指数（FSI）进行统计,应用SAS8.2软件包得出Fisher判别函数并与ITO法结果进行比较。结果全同胞对及无关个体对中共有等位基因数目均符合正态分布。采用Identifiler系统15个STR基因座共有等位基因数进行全同胞关系判别时,判别函数分别为：ZFS=3.26970S15-31.51174和ZUI=1.70058S15-8.52411。用上述判别函数进行全同胞/无关个体关系判别时的平均错判率为0.0298。15个STR基因座共有等位基因数法、CODIS13个STR基因座共有等位基因数法与ITO法判别结果差异无统计学意义。结论应用常染色体STR基因座的共有等位基因数判别全同胞关系简便、可信,易于掌握且不受STR基因座等位基因频率的影响。 |
| 关 键 词： | 法医遗传学 同胞关系 等位基因 短串联重复序列 判别分析 ITO法 |
Application of the Number of Allele Shared among Autosomal STR Loci in Full Sibling Identification |
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| ZHAO Shu-min,LI Cheng-tao,ZHANG Su-hua,LI Li,LIN Yuan,QUE Ting-zhi. Application of the Number of Allele Shared among Autosomal STR Loci in Full Sibling Identification[J]. Journal of Forensic Medicine, 2009, 25(4): 267-270. DOI: 10.3969/j.issn.1004-5619.2009.04.008 | |
| Authors: | ZHAO Shu-min LI Cheng-tao ZHANG Su-hua LI Li LIN Yuan QUE Ting-zhi |
| Affiliation: | ZHAO Shu-min1,LI Cheng-tao1,2,ZHANG Su-hua3,LI Li1,LIN Yuan1,QUE Ting-zhi1 (1. Shanghai Key Laboratory of Forensic Medicine,Institute of Forensic Science,Ministry of Justice,P.R. China,Shanghai 200063,China,2. School of Life Sciences,Fudan University,Shanghai 200433,3. Department of Forensic,Medical College of Soochow University,Suzhou 215123,China) |
| Abstract: | Objective To establish and evaluate the method of full sibling identification based on the number of allele shared among autosomal STR Loci. Methods Two hundred and eighty full sibling pairs and 2 003 unrelated individual pairs were genotyped in 15 STR loci with Identifiler Kit, and the number of allele shared among the 15 STR loci(S15) and full sibling index(FSI) were calculated. Fisher discriminant functions were established with SAS 8.2 software based on S15, the power of which were compared with ITO met... |
| Keywords: | forensic genetics sibling relations alleles short tandem repeat discriminant analysis ITO method |
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