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单核细胞趋化蛋白1及其受体在冠心病猝死中的表达
引用本文:匡圆圆,陈霞霞,王苍成,叶坤,王颖,史永华.单核细胞趋化蛋白1及其受体在冠心病猝死中的表达[J].法医学杂志,2014(6):413-415.
作者姓名:匡圆圆  陈霞霞  王苍成  叶坤  王颖  史永华
作者单位:新疆医科大学基础医学院,新疆 乌鲁木齐,830011
摘    要:目的:探讨单核细胞趋化蛋白1(monocyte chemotactic protein-1,MCP-1)及其受体CC类趋化蛋白受体2(CC chemokine receptor-2,CCR-2)在冠心病猝死(sudden coronary death,SCD)和非SCD冠状动脉粥样硬化斑块中的差异表达。方法应用免疫组织化学方法检测MCP-1和CCR-2在SCD组、动脉粥样硬化组(冠状动脉粥样硬化但非SCD)、对照组(冠状动脉正常)的差异表达。结果 MCP-1在三组间的阳性细胞表达率分别是78%、47%、0%,两两比较差异均有统计学意义(P<0.05);CCR-2在三组间的阳性细胞表达率分别是72%、47%、0%,在SCD组和动脉粥样硬化组、SCD组与对照组表达差异均有统计学意义(P〉0.05),而在对照组和动脉粥样硬化组差异无统计学意义(P〉0.05)。结论冠状动脉粥样硬化斑块中的MCP-1及其受体CCR-2的表达增加与SCD密切相关。

关 键 词:法医病理学  猝死  心脏  单核细胞趋化蛋白1  CC类趋化蛋白受体2

Expression of Monocyte Chemotactic Protein-1 and Its Receptor in Sudden Coro-nary Death
KUANG Yuan-yuan,CHEN Xia-xia,WANG Cang-cheng,YE Kun,WANG Ying,SHI Yong-hua.Expression of Monocyte Chemotactic Protein-1 and Its Receptor in Sudden Coro-nary Death[J].Journal of Forensic Medicine,2014(6):413-415.
Authors:KUANG Yuan-yuan  CHEN Xia-xia  WANG Cang-cheng  YE Kun  WANG Ying  SHI Yong-hua
Institution:(School of Basic Medical Science, Xinjiang Medical University, Urumqi 830011, China)
Abstract:Objective To investigate the expression of monocyte chemotactic protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR-2) in coronary atherosclerosis plaques between sudden coro- nary death (SCD) and non-SCD. Methods The expression levels of MCP-1 and CCR-2 in SCD group, coronary atherosclerosis group (non-SCD), control group (normal coronary artery) were detected by im- munohistochemistry. Results Positive rates of MCP-1 among the three groups were 78%, 47%, and 0%, respectively, with significant expressing differences between each two groups (P〈0.05). Positive rates of CCR-2 among three groups were 72%, 47%, and 0%, respectively, with significant expressing differ- ences between the SCD group and coronary atherosclerosis group as well as between the SCD group and control group (P〈0.05), but with no significant expressing difference between coronary atherosclero- sis group and control group (P〉0.05). Conclusion Overexpression of MCP-1 and CCR-2 in coronary atherosclerotic plaques is closely correlated with SCD.
Keywords:forensic pathology  death  sudden  cardiac  m onocyte chem otactic protein-1  C C chem okine protein receptor-2
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