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Sudden infant death syndrome (SIDS)--standardised investigations and classification: recommendations
Authors:Bajanowski Thomas  Vege Ashild  Byard Roger W  Krous Henry F  Arnestad Marianne  Bachs Liliana  Banner Jytte  Blair Peter S  Borthne Arne  Dettmeyer Reinhard  Fleming Peter  Gaustad Peter  Gregersen Markil  Grøgaard Jens  Holter Ellen  Isaksen Christina V  Jorgensen Jens V  de Lange Charlotte  Madea Burkhard  Moore Isabella  Morland Jorg  Opdal Siri H  Råsten-Almqvist Petra  Schlaud Martin  Sidebotham Peter  Skullerud Kari  Stoltenburg-Didinger Gisela  Stray-Pedersen Arne  Sveum Lisbeth  Rognum Torleiv O
Affiliation:Institute of Legal Medicine, University Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany. thomas.bajanowski@medizin.uni-essen.de
Abstract:Sudden infant death syndrome (SIDS) still accounts for considerable numbers of unexpected infant deaths in many countries. While numerous theories have been advanced to explain these events, it is increasingly clear that this group of infant deaths results from the complex interaction of a variety of heritable and idiosyncratic endogenous factors interacting with exogenous factors. This has been elegantly summarised in the "three hit" or "triple risk" model. Contradictions and lack of consistencies in the literature have arisen from diverse autopsy approaches, variable applications of diagnostic criteria and inconsistent use of definitions. An approach to sudden infant death is outlined with discussion of appropriate tissue sampling, ancillary investigations and the use of controls in research projects. Standardisation of infant death investigations with the application of uniform definitions and protocols will ensure optimal investigation of individual cases and enable international comparisons of trends.
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