Parallel artificial membrane permeability assay for blood–brain permeability determination of illicit drugs and synthetic analogues |
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| Institution: | 1. Department of Chemistry, Florence University, via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy;2. Department of Chemistry, University of Padova, Via Marzolo 1, 35131 Padova, Italy;3. Department of Agricultural and Food Science, University of Naples “Federico II”, 80055 Portici, Italy;4. Proteomics & Mass Spectrometry Laboratory, ISPAAM-National Research Council, 80147, Naples, Italy;5. School of Science, Engineering & Technology, Division of Food & Life Sciences, Abertay University, Kydd Building, Dundee DD1 1HG, UK;1. Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø N-9037, Norway;2. Natural Products and Medicinal Chemistry Research Group, Department of Pharmacy, University of Tromsø, Tromsø N-9037, Norway |
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| Abstract: | With the number of designer drugs on the streets rampantly on the rise, it's becoming more and more important to be able to rapidly characterize them in a biologically relevant way. Using a parallel artificial membrane permeability assay (PAMPA) to assess the blood brain barrier permeability has shown to be a high throughput way to compare new drugs with currently controlled substances via their effective permeability values. This combined with direct infusion electrospray ionization–mass spectrometry creates a rapid technique for characterization of new designer drugs. PAMPA has successfully determined the effective permeabilities of cocaine, methamphetamine, heroin, MDMA, and several tryptamine derivatives. |
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