GC/MS determination of zolpidem in postmortem specimens in a voluntary intoxication |
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Authors: | Keller T Schneider A Tutsch-Bauer E |
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Affiliation: | Institute of Forensic Medicine, Paris-Lodron University, Salzburg, Austria. |
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Abstract: | An ingestion of an unknown quantity of Ivadal (zolpidem) tablets in a case of drug abuse is described. The authors report a new and fast method of analysing and determining the zolpidem concentration in postmortem specimens. Quantitation of zolpidem was performed by ethyl acetate extraction from alkalinized body fluids before GC/MS analysis. The analyses were performed without any complex sample clean-up steps and with little sample material. Postmortem concentrations of zolpidem in body fluids are given. The proposed method is a rapid procedure of analysis in cases of deliberate poisoning with the sedative-hypnotic drug, zolpidem. |
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