| 鸡阿奇霉素急性中毒的病理学研究 |
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| 引用本文： | 李梦云,彭西,李英伦,崔恒敏. 鸡阿奇霉素急性中毒的病理学研究[J]. 中国兽医科学, 2010, 40(2) |
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| 作者姓名： | 李梦云 彭西 李英伦 崔恒敏 |
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| 作者单位： | 李梦云(河南科技大学,动物科技学院,河南,洛阳,471003;四川农业大学,动物医学院,四川,雅安,625014);彭西,李英伦,崔恒敏(四川农业大学,动物医学院,四川,雅安,625014) |
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| 基金项目： | 四川省教育厅重点项目 |
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| 摘 要： | 以大发乌骨蛋鸡为研究对象,采用一次性灌胃给药法进行阿奇霉素的急性毒性试验,研究了试验鸡对阿奇霉素的毒性反应和病理变化.结果显示,阿奇霉素对鸡的半数致死量为4.57 g/kg,雏鸡急性中毒20 min后,出现明显的临床症状,主要表现为精神委靡,呼吸困难,食欲减退,且呈明显的量效关系.组织病理学变化主要为肝细胞颗粒变性和脂肪变性;肺淤血;肾小管上皮细胞和消化道黏膜上皮变性坏死.证实,阿奇霉素急性中毒会广泛损害雏鸡肝、肺、肾和肠等多种组织器官,甚至引起这些组织器官的变性坏死.
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| 关 键 词： | 阿奇霉素 急性中毒 半数致死量 病理学变化 雏鸡 |
Pathological observation of chickens with acute toxicity induced by azithromycin |
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| LI Meng-yun,,PENG Xi,LI Ying-lun,CUI Heng-min. Pathological observation of chickens with acute toxicity induced by azithromycin[J]. Chinese Veterinary Science, 2010, 40(2) |
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| Authors: | LI Meng-yun PENG Xi LI Ying-lun CUI Heng-min |
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| Affiliation: | LI Meng-yun1,2,PENG Xi2,LI Ying-lun2,CUI Heng-min2(1.College of Animal Science & Veterinary Medicine,Henan University of Science , Technology,Luoyang 471003,China,2.College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China) |
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| Abstract: | An acute toxicity experiment of azithromycin was conducted into Dafa black-bone egg chic-kens.The clinical signs and histopathological changes were observed in chickens intragastrically administrated with azithromycin.In result,the median lethal dose was 4.57 g/kg to the chickens according to body weight,and the affected chickens showed obviously clinical symptoms including depression,dyspneic respiration and loss of appetite in dose-dependence after 20 minutes post-administration.Histopathologically,the he... |
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| Keywords: | azithromycin acute toxicity LD50 pathologic change chicken |
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